Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Main Polymorphisms in Aspirin-Exacerbated Respiratory Disease

Fri May 24 22:50:36 2024

(2023) Main Polymorphisms in Aspirin-Exacerbated Respiratory Disease. Gene. p. 147326. ISSN 1879-0038 (Electronic) 0378-1119 (Linking)

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Aspirin exacerbated respiratory disease (AERD) is a condition caused by increased bronchoconstriction in people with asthma after taking aspirin or another NSAID. Molecular analysis of the human genome has opened up new perspectives on human polymorphisms and disease. This study was conducted to identify the genetic factors that influence this disease due to its unknown genetic factors. We evaluated research studies, letters, comments, editorials, eBooks, and reviews. PubMed/MEDLINE, Web of Sciences, Cochrane Library, and Scopus were searched for information. We used the keywords polymorphisms, aspirin-exacerbated respiratory disease, asthma, allergy as search terms. This study included 38 studies. AERD complications were associated with polymorphisms in ALOX15, EP2, ADRB2, SLC6A12, CCR3, CRTH2, CysLTs, DPCR1, DPP10, FPR2, HSP70, IL8, IL1B, IL5RA, IL-13, IL17RA, ILVBL, TBXA2R, TLR3, HLA-DRB and HLA-DQ, HLA-DR7, HLA-DP. AERD was associated with heterogeneity in gene polymorphisms, making it difficult to pinpoint specific gene changes. Therefore, diagnosing and treating AERD may be facilitated by examining common variants involving the disease.

Item Type: Article
Fathollahpour, A.UNSPECIFIED
Nasiri Kalmarzi, R.UNSPECIFIED
Keywords: Aspirin-Exacerbated Respiratory Disease Polymorphisms allergy asthma competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Page Range: p. 147326
Journal or Publication Title: Gene
Journal Index: Pubmed
Identification Number:
ISSN: 1879-0038 (Electronic) 0378-1119 (Linking)
Depositing User: مهندس مهدی شریفی

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