Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The prevalence of clarithromycin-resistant Helicobacter pylori isolates: a systematic review and meta-analysis

Mon Feb 26 08:39:00 2024

(2023) The prevalence of clarithromycin-resistant Helicobacter pylori isolates: a systematic review and meta-analysis. PeerJ. e15121. ISSN 2167-8359 (Electronic) 2167-8359 (Linking)

Full text not available from this repository.

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/37016679

Abstract

BACKGROUND: Knowledge of global clarithromycin (CLA)-resistant rates of Helicobacter pylori (H. pylori) is crucial for decision of the most appropriate eradication therapies with good clinical outcomes. Therefore, this review and meta-analysis aimed to evaluate the global prevalence of the CLA resistance in H. pylori to provide some guidance for selecting the first-line antibiotics. METHOD: A comprehensive search was performed for relevant literature until April 2021 in PubMed, Embase, and Web of Science databases. Freeman-Tukey double arcsine transformation was performed to estimate the weighted pooled prevalence of resistance. RESULTS: The meta-analysis included 248 articles. The prevalence of CLA-resistant H. pylori was 27.53 (95 CI 25.41-29.69). The heterogeneity between reports was significant (I(2) = 97.80%, P < 0.01). The resistance rate increased from 24.28% in 2010-2017 to 32.14% in 2018-2021 (P < 0.01). Iran, with 38 articles, has the most report. Nevertheless, Switzerland, Portugal, and Israel had the highest resistance rates (67.16%, 48.11%, and 46.12%, respectively). The heterogeneity between the continents and the antimicrobial susceptibility methods also interpreted standard guidelines and breakpoints was insignificant (P > 0.05). CONCLUSION: Overall CLA resistance rate was 27.53%, worldwide. The difference in CLA resistance rate among the included studies can be due to several reasons such as differences in antibiotic prescription rates in various geographic areas, use of different breakpoints or inaccurate criteria in performed studies, and the emergence of multidrug-resistant (MDR) strains.

Item Type: Article
Creators:
CreatorsEmail
Sholeh, M.UNSPECIFIED
Khoshnood, S.UNSPECIFIED
Azimi, T.UNSPECIFIED
Mohamadi, J.UNSPECIFIED
Kaviar, V. H.UNSPECIFIED
Hashemian, M.UNSPECIFIED
Karamollahi, S.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Heidarizadeh, H.UNSPECIFIED
Heidary, M.UNSPECIFIED
Saki, M.UNSPECIFIED
Keywords: Humans Clarithromycin/pharmacology *Helicobacter pylori *Helicobacter Infections/drug therapy Prevalence Drug Resistance, Bacterial Anti-Bacterial Agents/pharmacology Antibiotic resistance Clarithromycin Helicobacter pylori Meta-analysis competing interests.
Divisions:
Page Range: e15121
Journal or Publication Title: PeerJ
Journal Index: Pubmed
Volume: 11
Identification Number: https://doi.org/10.7717/peerj.15121
ISSN: 2167-8359 (Electronic) 2167-8359 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4251

Actions (login required)

View Item View Item