Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Effects of Dietary Supplements of Calcium, Vitamin D and Estrogen Hormone on Serum Levels of OPG and RANKL Cytokines and their Relationship with Increased Bone Density in Rats

Sat Apr 20 13:47:45 2024

(2016) The Effects of Dietary Supplements of Calcium, Vitamin D and Estrogen Hormone on Serum Levels of OPG and RANKL Cytokines and their Relationship with Increased Bone Density in Rats. Journal of Clinical and Diagnostic Research. AF1-AF4. ISSN 2249-782X

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Abstract

Introduction: Osteoprotegerin (OPG)-Receptor activator of nuclear factor kappa-B ligand(RANKL) pathway is one of the contributing factors in the regulation of osteogenesis and bone resorption routes. Aim: The purpose of this study was to evaluate the effects of various dietary supplements on this pathway. Materials and Methods: The samples for this study (24 newborn rats) were divided in three groups according to the experiment applied for each group. Rats were given special diet according to their group plan for six weeks. Blood samples were collected to measure their serum levels of OPG and RANKL and all organs of rats were used to measure their bone density too. The results were analysed using appropriate statistical analysing tests. Results: Levels of whole-body bone mineral density in calcium plus vitamin D plus Estrogen (Ca + D + E) group and calcium plus vitamin D (Ca + D) group were significantly increased compared to control group. Mineral density was highest in calcium plus vitamin D plus Estrogen group and was about 0.1357 g/cm(2). RANKL had a significant decrease in calcium plus vitamin D plus Estrogen group compared to control and calcium plus vitamin D groups. There was a significant increase in the mean calcium and OPG in both experimental groups rather than control. Also, significant increase in estrogen was observed in Ca + D group than the control group. Conclusion: The results showed that intake of calcium and vitamin D and estrogen at determined dose led to an increase in OPG and RANKL cytokines reduction which ultimately led to an increase in bone mineral density. But Ca, D and E synergies were more effective in increasing bone mineral density compared to only the use of Ca and D.

Item Type: Article
Creators:
CreatorsEmail
Piri, F.UNSPECIFIED
Khosravi, A.UNSPECIFIED
Moayeri, A.UNSPECIFIED
Moradipour, A.UNSPECIFIED
Derakhshan, S.UNSPECIFIED
Keywords: Estradiol Osteoblast Osteoclast mineral density postmenopausal women receptor activator osteoporosis osteoprotegerin association infection General & Internal Medicine
Divisions:
Page Range: AF1-AF4
Journal or Publication Title: Journal of Clinical and Diagnostic Research
Journal Index: ISI
Volume: 10
Number: 9
Identification Number: https://doi.org/10.7860/jcdr/2016/18648.8433
ISSN: 2249-782X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/425

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