Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019

Wed May 22 11:15:21 2024

(2022) Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. pp. 2221-2248. ISSN 0140-6736

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Official URL: <Go to ISI>://WOS:000928263900001

Abstract

Background Reducing the burden of death due to infection is an urgent global public health priority. Previous studies have estimated the number of deaths associated with drug-resistant infections and sepsis and found that infections remain a leading cause of death globally. Understanding the global burden of common bacterial pathogens (both susceptible and resistant to antimicrobials) is essential to identify the greatest threats to public health. To our knowledge, this is the first study to present global comprehensive estimates of deaths associated with 33 bacterial pathogens across 11 major infectious syndromes. Methods We estimated deaths associated with 33 bacterial genera or species across 11 infectious syndromes in 2019 using methods from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, in addition to a subset of the input data described in the Global Burden of Antimicrobial Resistance 2019 study. This study included 343 million individual records or isolates covering 11 361 study-location-years. We used three modelling steps to estimate the number of deaths associated with each pathogen: deaths in which infection had a role, the fraction of deaths due to infection that are attributable to a given infectious syndrome, and the fraction of deaths due to an infectious syndrome that are attributable to a given pathogen. Estimates were produced for all ages and for males and females across 204 countries and territories in 2019. 95 uncertainty intervals (UIs) were calculated for final estimates of deaths and infections associated with the 33 bacterial pathogens following standard GBD methods by taking the 2.5th and 97.5th percentiles across 1000 posterior draws for each quantity of interest. Findings From an estimated 13.7 million (95 UI 10.9-17.1) infection-related deaths in 2019, there were 7.7 million deaths (5.7-10.2) associated with the 33 bacterial pathogens (both resistant and susceptible to antimicrobials) across the 11 infectious syndromes estimated in this study. We estimated deaths associated with the 33 bacterial pathogens to comprise 13.6 (10.2-18.1) of all global deaths and 56.2 (52.1-60.1) of all sepsis-related deaths in 2019. Five leading pathogens-Staphylococcus aureus, Escherichia coli, Streptococcus pneumoniae, Klebsiella pneumoniae, and Pseudomonas aeruginosa-were responsible for 54.9 (52.9-56.9) of deaths among the investigated bacteria. The deadliest infectious syndromes and pathogens varied by location and age. The age-standardised mortality rate associated with these bacterial pathogens was highest in the sub-Saharan Africa super-region, with 230 deaths (185-285) per 100 000 population, and lowest in the high-income super-region, with 52.2 deaths (37.4-71.5) per 100 000 population. S aureus was the leading bacterial cause of death in 135 countries and was also associated with the most deaths in individuals older than 15 years, globally. Among children younger than 5 years, S pneumoniae was the pathogen associated with the most deaths. In 2019, more than 6 million deaths occurred as a result of three bacterial infectious syndromes, with lower respiratory infections and bloodstream infections each causing more than 2 million deaths and peritoneal and intra-abdominal infections causing more than 1 million deaths. Interpretation The 33 bacterial pathogens that we investigated in this study are a substantial source of health loss globally, with considerable variation in their distribution across infectious syndromes and locations. Compared with GBD Level 3 underlying causes of death, deaths associated with these bacteria would rank as the second leading cause of death globally in 2019; hence, they should be considered an urgent priority for intervention within the global health community. Strategies to address the burden of bacterial infections include infection prevention, optimised use of antibiotics, improved capacity for microbiological analysis, vaccine development, and improved and more pervasive use of available vaccines. These estimates can be used to help set priorities for vaccine need, demand, and development. Copyright (c) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.

Item Type: Article
Creators:
CreatorsEmail
Ikuta, K. S.UNSPECIFIED
Swetschinski, L. R.UNSPECIFIED
Aguilar, G. R.UNSPECIFIED
Sharara, F.UNSPECIFIED
Mestrovic, T.UNSPECIFIED
Gray, A. P.UNSPECIFIED
Weaver, N. D.UNSPECIFIED
Wool, E. E.UNSPECIFIED
Han, C.UNSPECIFIED
Hayoon, A. G.UNSPECIFIED
Aali, A.UNSPECIFIED
Abate, S. M.UNSPECIFIED
Abbasi-Kangevari, M.UNSPECIFIED
Abbasi-Kangevari, Z.UNSPECIFIED
Abd-Elsalam, S.UNSPECIFIED
Abebe, G.UNSPECIFIED
Abedi, A.UNSPECIFIED
Abhari, A. P.UNSPECIFIED
Abidi, H.UNSPECIFIED
Aboagye, R. G.UNSPECIFIED
Absalan, A.UNSPECIFIED
Ali, H. A.UNSPECIFIED
Acuna, J. M.UNSPECIFIED
Adane, T. D.UNSPECIFIED
Addo, I. Y.UNSPECIFIED
Adegboye, O. A.UNSPECIFIED
Adnan, M.UNSPECIFIED
Adnani, Q. E. S.UNSPECIFIED
Afzal, M. S.UNSPECIFIED
Afzal, S.UNSPECIFIED
Aghdam, Z. B.UNSPECIFIED
Ahinkorah, B. O.UNSPECIFIED
Ahmad, A.UNSPECIFIED
Ahmad, A. R.UNSPECIFIED
Ahmad, R.UNSPECIFIED
Ahmad, S.UNSPECIFIED
Ahmad, S.UNSPECIFIED
Ahmadi, S.UNSPECIFIED
Ahmed, A.UNSPECIFIED
Ahmed, H.UNSPECIFIED
Ahmed, J. Q.UNSPECIFIED
Rashid, T. A.UNSPECIFIED
Ajami, M.UNSPECIFIED
Aji, B.UNSPECIFIED
Akbarzadeh-Khiavi, M.UNSPECIFIED
Akunna, C. J.UNSPECIFIED
Al Hamad, H.UNSPECIFIED
Alahdab, F.UNSPECIFIED
Al-Aly, Z.UNSPECIFIED
Aldeyab, M. A.UNSPECIFIED
Aleman, A. V.UNSPECIFIED
Alhalaiqa, F. A. N.UNSPECIFIED
Alhassan, R. K.UNSPECIFIED
Ali, B. A.UNSPECIFIED
Ali, L.UNSPECIFIED
Ali, S. S.UNSPECIFIED
Alimohamadi, Y.UNSPECIFIED
Alipour, V.UNSPECIFIED
Alizadeh, A.UNSPECIFIED
Aljunid, S. M.UNSPECIFIED
Allel, K.UNSPECIFIED
Almustanyir, S.UNSPECIFIED
Ameyaw, E. K.UNSPECIFIED
Amit, A. M. L.UNSPECIFIED
Anandavelane, N.UNSPECIFIED
Ancuceanu, R.UNSPECIFIED
Andrei, C. L.UNSPECIFIED
Andrei, T.UNSPECIFIED
Anggraini, D.UNSPECIFIED
Ansar, A.UNSPECIFIED
Anyasodor, A. E.UNSPECIFIED
Arabloo, J.UNSPECIFIED
Aravkin, A. Y.UNSPECIFIED
Areda, D.UNSPECIFIED
Aripov, T.UNSPECIFIED
Artamonov, A. A.UNSPECIFIED
Arulappan, J.UNSPECIFIED
Aruleba, R. T.UNSPECIFIED
Asaduzzaman, M.UNSPECIFIED
Ashraf, T.UNSPECIFIED
Athari, S. S.UNSPECIFIED
Atlaw, D.UNSPECIFIED
Attia, S.UNSPECIFIED
Ausloos, M.UNSPECIFIED
Awoke, T.UNSPECIFIED
Quintanilla, B. P. A.UNSPECIFIED
Ayana, T. M.UNSPECIFIED
Azadnajafabad, S.UNSPECIFIED
Jafari, A. A.UNSPECIFIED
Darshan, B. B.UNSPECIFIED
Badar, M.UNSPECIFIED
Badiye, A. D.UNSPECIFIED
Baghcheghi, N.UNSPECIFIED
Bagherieh, S.UNSPECIFIED
Baig, A. A.UNSPECIFIED
Banerjee, I.UNSPECIFIED
Barac, A.UNSPECIFIED
Bardhan, M.UNSPECIFIED
Barone-Adesi, F.UNSPECIFIED
Barqawi, H. J.UNSPECIFIED
othersUNSPECIFIED
Keywords: streptococcus-pneumoniae antimicrobial resistance strategies vaccines sepsis infections guidelines management children health General & Internal Medicine
Divisions:
Page Range: pp. 2221-2248
Journal or Publication Title: Lancet
Journal Index: ISI
Volume: 400
Number: 10369
Identification Number: https://doi.org/10.1016/s0140-6736(22)02185-7
ISSN: 0140-6736
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4249

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