Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Anesthesia and analgesia for common research models of adult mice

Mon May 27 07:24:30 2024

(2022) Anesthesia and analgesia for common research models of adult mice. Laboratory Animal Research. p. 16. ISSN 1738-6055

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Official URL: <Go to ISI>://WOS:000920715500001

Abstract

Anesthesia and analgesia are major components of many interventional studies on laboratory animals. However, various studies have shown improper reporting or use of anesthetics/analgesics in research proposals and published articles. In many cases, it seems "anesthesia " and "analgesia " are used interchangeably, while they are referring to two different concepts. Not only this is an unethical practice, but also it may be one of the reasons for the proven suboptimal quality of many animal researches. This is a widespread problem among investigations on various species of animals. However, it could be imagined that it may be more prevalent for the most common species of laboratory animals, such as the laboratory mice. In this review, proper anesthetic/analgesic methods for routine procedures on laboratory mice are discussed. We considered the available literature and critically reviewed their anesthetic/analgesic methods. Detailed dosing and pharmacological information for the relevant drugs are provided and some of the drugs' side effects are discussed. This paper provides the necessary data for an informed choice of anesthetic/analgesic methods in some routine procedures on laboratory mice.

Item Type: Article
Creators:
CreatorsEmail
Ahmadi-Noorbakhsh, S.UNSPECIFIED
Abbasi, M. F.UNSPECIFIED
Ghasemi, M.UNSPECIFIED
Bayat, G.UNSPECIFIED
Davoodian, N.UNSPECIFIED
Sharif-Paghaleh, E.UNSPECIFIED
Poormoosavi, S. M.UNSPECIFIED
Rafizadeh, M.UNSPECIFIED
Maleki, M.UNSPECIFIED
Shirzad-Aski, H.UNSPECIFIED
Jahromi, H. K.UNSPECIFIED
Dadkhah, M.UNSPECIFIED
Khalvati, B.UNSPECIFIED
Safari, T.UNSPECIFIED
Behmanesh, M. A.UNSPECIFIED
Khoshnam, S. E.UNSPECIFIED
Houshmand, G.UNSPECIFIED
Talaei, S. A.UNSPECIFIED
Keywords: Anesthetic Analgesic Mouse Pharmacology Side effect Preclinical experimental myocardial-infarction ketamine-xylazine anesthesia bile-duct ligation mouse model isoflurane anesthesia renovascular hypertension gastrointestinal motility reperfusion injury laboratory mice cecal ligation Research & Experimental Medicine Veterinary Sciences
Divisions:
Page Range: p. 16
Journal or Publication Title: Laboratory Animal Research
Journal Index: ISI
Volume: 38
Number: 1
Identification Number: https://doi.org/10.1186/s42826-022-00150-3
ISSN: 1738-6055
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4246

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