Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Circular RNAs and tuberculosis infection

Sun May 26 11:55:01 2024

(2023) Circular RNAs and tuberculosis infection. International Journal of Biological Macromolecules. pp. 1218-1225. ISSN 0141-8130

Full text not available from this repository.

Official URL: <Go to ISI>://WOS:000923013400001

Abstract

Tuberculosis (TB) is a deadly infectious disease caused by Mycobacterium tuberculosis (Mtb) that affects the im-mune system chronically. Therefore, effective control and treatment of tuberculosis requires rapid and accurate diagnostic strategies. Tuberculosis has always been a global burden on health, social and economic systems due to the lack of standard curative and diagnostic (bio)markers. Accordingly, the management and monitoring of patients with active TB at the primary care level may be possible through new, rapid and cost-effective non -sputum-based diagnostic procedures. Biomarkers can help diagnose various diseases, including circular RNA (circRNA), which has recently been introduced as an endogenous, abundant and stable RNA in the cytoplasm with unique tissue specificity. There are frequent reports of circRNA involvement in many pathological and physiological processes in human beings. Recent studies have highlighted the presence of circRNAs in serum and their role as promising biomarkers in the diagnosis of the disease, potentially due to the continuous, stable, closed covalent circular structures and lack of easy degradation by nucleases. The purpose of this review article is to scrutinize the behavior of circulating plasma RNAs in relation to the pathogenesis and diagnosis of tuberculosis.

Item Type: Article
Creators:
CreatorsEmail
Hemati, Z.UNSPECIFIED
Neamati, F.UNSPECIFIED
Khaledi, M.UNSPECIFIED
Gheibihayat, S. M.UNSPECIFIED
Jafarzadeh, L.UNSPECIFIED
Momen-Heravi, M.UNSPECIFIED
Haddadi, M. H.UNSPECIFIED
Sameni, F.UNSPECIFIED
Fathizadeh, H.UNSPECIFIED
Keywords: Non-coding RNA Circular RNAs CircRNAs Biomarker Mycobacterium tuberculosis Tuberculosis infection blood mononuclear-cells peripheral-blood diagnostic biomarker emerging role expression Biochemistry & Molecular Biology Chemistry Polymer Science
Divisions:
Page Range: pp. 1218-1225
Journal or Publication Title: International Journal of Biological Macromolecules
Journal Index: ISI
Volume: 226
Identification Number: https://doi.org/10.1016/j.ijbiomac.2022.11.235
ISSN: 0141-8130
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4243

Actions (login required)

View Item View Item