Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

rs12329760 Polymorphism in Transmembrane Serine Protease 2 Gene and Risk of Coronavirus Disease 2019 Mortality

Sat Apr 20 23:53:28 2024

(2022) rs12329760 Polymorphism in Transmembrane Serine Protease 2 Gene and Risk of Coronavirus Disease 2019 Mortality. Biomed Research International. p. 8. ISSN 2314-6133

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Official URL: <Go to ISI>://WOS:000896113300001

Abstract

The protease produced by the transmembrane serine protease 2 (TMPRSS2) gene enhances viral infections and has been linked to severe acute respiratory syndrome coronavirus 2 pathogenesis. Therefore, this study evaluated the association between TMPRSS2 and coronavirus disease 2019 (COVID-19) mortality. TMPRSS2 rs12329760 polymorphism was genotyped using the tetraprimer amplification refractory mutation system-polymerase chain reaction method in 592 dead and 693 improved patients. In the current study, the frequency of TMPRSS2 rs12329760 CC than TT genotypes was significantly lower in improved patients than in dead patients. According to the findings of the multivariate logistic regression test, higher levels of mean age, creatinine, erythrocyte sedimentation rate, C-reactive protein, aspartate aminotransferase, lower levels of 25-hydroxyvitamin D, uric acid, and real-time PCR Ct values and TMPRSS2 rs12329760 CC genotype were observed to be associated with increased COVID-19 mortality rates. In conclusion, the TMPRSS2 rs12329760 CC genotype was a polymorphism linked to a significantly higher incidence of severe COVID-19. Further studies are required to corroborate the obtained findings.

Item Type: Article
Creators:
CreatorsEmail
Shirazi, S. S. B.UNSPECIFIED
Sakhaee, F.UNSPECIFIED
Sotoodehnejadnematalahi, F.UNSPECIFIED
Zamani, M. S.UNSPECIFIED
Ahmadi, I.UNSPECIFIED
Anvari, E.UNSPECIFIED
Fateh, A.UNSPECIFIED
Keywords: tmprss2 susceptibility covid-19 Biotechnology & Applied Microbiology Research & Experimental Medicine
Divisions:
Page Range: p. 8
Journal or Publication Title: Biomed Research International
Journal Index: ISI
Volume: 2022
Identification Number: https://doi.org/10.1155/2022/7841969
ISSN: 2314-6133
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4222

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