Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants

Sun Jul 14 17:31:58 2024

(2023) Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants. Human Genomics. p. 9. ISSN 1473-9542

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Official URL: <Go to ISI>://WOS:000945342200001

Abstract

BackgroundPolymorphisms in the interleukin-10 (IL10) gene have been linked to the severity of the patients infected with the viral infections. This study aimed to assess if the IL10 gene polymorphisms rs1800871, rs1800872, and rs1800896 were linked to coronavirus disease 19 (COVID-19) mortality in different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in the Iranian population.MethodsFor genotyping IL10 rs1800871, rs1800872, and rs1800896, this study used the polymerase chain reaction-restriction fragment length polymorphism method in 1,734 recovered and 1,450 deceased patients.ResultsThe obtained finding indicated IL10 rs1800871 CC genotype in the Alpha variant and CT genotype in the Delta variant had a relationship with COVID-19 mortality; however, there was no association between rs1800871 polymorphism and the Omicron BA.5 variant. The COVID-19 mortality rate was associated with IL10 rs1800872 TT genotype in the Alpha and Omicron BA.5 variants and GT in the Alpha and Delta variants. The COVID-19 mortality rate was associated with IL10 rs1800896 GG and AG genotypes in the Delta and Omicron BA.5; nevertheless, there was no association between rs1800896 polymorphism with the Alpha variant. According to the obtained data, the GTA haplotype was the most common of haplotype in different SARS-CoV-2 variants. The TCG haplotype was related to COVID-19 mortality in the Alpha, Delta and Omicron BA.5 variants.ConclusionThe IL10 polymorphisms had an impact on COVID-19 infection, and these polymorphisms had different effects in various SARS-CoV-2 variants. To verify the obtained results, further studies should be conducted on various ethnic groups.

Item Type: Article
Creators:
CreatorsEmail
Abbood, S. J. A.UNSPECIFIED
Anvari, E.UNSPECIFIED
Fateh, A.UNSPECIFIED
Keywords: COVID-19 SARS-CoV-2 variants Interleukin-10 gene polymorphisms disease severity il-10 Genetics & Heredity
Divisions:
Page Range: p. 9
Journal or Publication Title: Human Genomics
Journal Index: ISI
Volume: 17
Number: 1
Identification Number: https://doi.org/10.1186/s40246-023-00468-6
ISSN: 1473-9542
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4219

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