Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Interactions of melatonin with various signaling pathways: implications for cancer therapy

Wed Feb 21 05:19:14 2024

(2022) Interactions of melatonin with various signaling pathways: implications for cancer therapy. Cancer Cell International. p. 18.

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Official URL: <Go to ISI>://WOS:000905956700001

Abstract

Melatonin is a neuro-hormone with conserved roles in evolution. Initially synthetized as an antioxidant molecule, it has gained prominence as a key molecule in the regulation of the circadian rhythm. Melatonin exerts its effect by binding to cytoplasmic and intra-nuclear receptors, and is able to regulate the expression of key mediators of different signaling pathways. This ability has led scholars to investigate the role of melatonin in reversing the process of carcinogenesis, a process in which many signaling pathways are involved, and regulating these pathways may be of clinical significance. In this review, the role of melatonin in regulating multiple signaling pathways with important roles in cancer progression is discussed, and evidence regarding the beneficence of targeting malignancies with this approach is presented.

Item Type: Article
Creators:
CreatorsEmail
Mihanfar, A.UNSPECIFIED
Yousefi, B.UNSPECIFIED
Azizzadeh, B.UNSPECIFIED
Majidinia, M.UNSPECIFIED
Keywords: Melatonin Anti-cancer Signaling pathways factor-kappa-b inhibits tumor-growth long noncoding rnas breast-cancer cell-death mesenchymal transition pi3k/akt/mtor pathway ovarian-cancer mapk pathway beta-catenin Oncology
Divisions:
Page Range: p. 18
Journal or Publication Title: Cancer Cell International
Journal Index: ISI
Volume: 22
Number: 1
Identification Number: https://doi.org/10.1186/s12935-022-02825-2
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4208

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