Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

View of the Renin-Angiotensin System in Acute Kidney Injury Induced by Renal Ischemia-Reperfusion Injury

Thu Apr 18 23:11:02 2024

(2022) View of the Renin-Angiotensin System in Acute Kidney Injury Induced by Renal Ischemia-Reperfusion Injury. Journal of the Renin-Angiotensin-Aldosterone System. p. 10. ISSN 1470-3203

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Official URL: <Go to ISI>://WOS:000878248600001

Abstract

Renal ischemia-reperfusion injury (RIRI) is a sequence of complicated events that is defined as a reduction of the blood supply followed by reperfusion. RIRI is the leading cause of acute kidney injury (AKI). Among the diverse mediators that take part in RIRI-induced AKI, the renin-angiotensin system (RAS) plays an important role via conventional (angiotensinogen, renin, angiotensin-converting enzyme (ACE), angiotensin (Ang) II, and Ang II type 1 receptor (AT(1)R)) and nonconventional (ACE2, Ang 1-7, Ang 1-9, AT(2) receptor (AT(2)R), and Mas receptor (MasR)) axes. RIRI alters the balance of both axes so that RAS can affect RIRI-induced AKI. In overall, the alteration of Ang II/AT(1)R and AKI by RIRI is important to consider. This review has looked for the effects and interactions of RAS activities during RIRI conditions.

Item Type: Article
Creators:
CreatorsEmail
Karimi, F.UNSPECIFIED
Maleki, M.UNSPECIFIED
Nematbakhsh, M.UNSPECIFIED
Keywords: converting enzyme-inhibitors decompensated heart-failure nitric-oxide synthase ischemia/reperfusion injury urinary angiotensinogen aldosterone system at2 receptors mas receptor intrarenal angiotensin promotes autophagy Cardiovascular System & Cardiology
Divisions:
Page Range: p. 10
Journal or Publication Title: Journal of the Renin-Angiotensin-Aldosterone System
Journal Index: ISI
Volume: 2022
Identification Number: https://doi.org/10.1155/2022/9800838
ISSN: 1470-3203
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4201

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