Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The effects of prebiotic supplementation on weight gain, diarrhoea, constipation, fever and respiratory tract infections in the first year of life

Wed Dec 7 06:32:35 2022

(2018) The effects of prebiotic supplementation on weight gain, diarrhoea, constipation, fever and respiratory tract infections in the first year of life. Journal of Paediatrics and Child Health. pp. 875-880. ISSN 1034-4810

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Abstract

AimThis study was conducted to evaluate the effect of prebiotics on some common clinical ailments in healthy term infants. MethodsSixty healthy-term, breastfed (BF) infants were included. Along with these infants, 120 healthy-term formula-fed infants were randomly assigned to either the prebiotic formula (PF, n = 60) or regular formula (RF, n = 60) groups. Ready-to-use prebiotic-supplemented formula containing galacto-oligosaccharides and polydextrose (ratio 1:1) was used. ResultsAt 2 months of age, PF infants demonstrated significantly higher weight gain than BF and RF. At 6 months of age, bodyweight was significantly higher in the RF group compared to BF and PF groups (P < 0.05). Similar results were seen at 8, 10 and 12 months of age. At 10 months of age, the duration of diarrhoea was significantly shorter in PF-fed compared to the RF (P = 0.03) group. A significant difference was found between PF and RF (P < 0.0001) and BF and RF groups (P = 0.002) for diarrhoea duration. Means of constipation episodes per year were 0.03 0.18, 0.433 +/- 0.77 and 0.1 +/- 0.30 for the BF, RF and PF groups, respectively, with significant difference found between BF and RF (P = 0.006) and PF and RF (P = 0.02). The means of episodes of respiratory tract infections per year for BF, RF and PF groups were 1 +/- 0.69, 1.6 +/- 0.88 and 1 +/- 0.58, respectively (P = 0.01). ConclusionPrebiotic-supplemented and regular formula were similar to breast milk regarding prophylactic effects for diarrhoea, constipation and respiratory tract infections in the first year of life. Prebiotic-supplemented formula may be an appropriate substitution for breast milk when breast milk in unavailable.

Item Type: Article
Creators:
CreatorsEmail
Shahramian, I.UNSPECIFIED
Kalvandi, G.UNSPECIFIED
Javaherizadeh, H.UNSPECIFIED
Khalili, M.UNSPECIFIED
Noori, N. M.UNSPECIFIED
Delaramnasab, M.UNSPECIFIED
Bazi, A.UNSPECIFIED
Keywords: constipation diarrhoea neonate prebiotics respiratory tract infection human-milk oligosaccharides placebo-controlled trial preterm infants term infants galacto-oligosaccharides double-blind in-vitro formula microbiota children Pediatrics
Divisions:
Page Range: pp. 875-880
Journal or Publication Title: Journal of Paediatrics and Child Health
Journal Index: ISI
Volume: 54
Number: 8
Identification Number: https://doi.org/10.1111/jpc.13906
ISSN: 1034-4810
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/42

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