Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association between GSTM1, GSTT1, and GSTP1 variants and the risk of end stage renal disease

Mon Nov 28 15:59:27 2022

(2016) Association between GSTM1, GSTT1, and GSTP1 variants and the risk of end stage renal disease. Renal Failure. pp. 1455-1461. ISSN 0886-022X

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Abstract

Introduction: There are some evidences indicating DNA damage by oxidant and mutant agents has an essential role in the chronic renal failure and end stage renal disease (ESRD). To investigate the possible association of GSTs variants with ESRD, we investigated the frequency of GST- T1, M1, and P1 genotypes, and the level of malondialdehyde (MDA) in patients with ESRD.Materials and methods: The present case-control study consisted of 136 ESRD patients treated with maintenance hemodialysis and 137 gender- and age-matched, unrelated healthy controls from the population of west of Iran. The GST- T1, M1, and P1 genotypes were determined in all individuals using multiplex-PCR and PCR-RFLP. The level of MDA was measured by high-performance liquid chromatography (HPLC).Results: We found that GSTM1 and GSTT1 null genotypes (GSTT1-/GSTM1-) increased the risk of ESRD by 1.8 times (p<0.001) and the increased risk of ESRD for GSTM-null (T1+-M1-) genotype was 3.04 times (p=0.002). ESRD patients carriers the GST (GSTM1-null+GSTT1-null+GST-null) genotypes compared to GST normal genotype increased the risk of ESRD by 3.3 (p<0.001) times. ESRD patients carriers of GST-null, GSTM1-null, and GSTT1-null genotypes had greater MDA concentration compared with the same genotypes of control subjects. Our results indicated that the GST-null allele (GSTT1-null/GSTM1-null) is a risk factor for ESRD and carriers of this allele have high levels of MDA.Conclusion: Our findings indicate that oxidative stress, impairment of the antioxidant system and abnormal lipid metabolism may play a role in the pathogenesis and progression of ESRD and its related complications. These data suggest that patients with ESRD are more susceptible to vascular diseases.

Item Type: Article
Creators:
CreatorsEmail
Nomani, H.UNSPECIFIED
Hagh-Nazari, L.UNSPECIFIED
Aidy, A.UNSPECIFIED
Vaisi-Raygani, A.UNSPECIFIED
Kiani, A.UNSPECIFIED
Rahimi, Z.UNSPECIFIED
Bahrehmand, F.UNSPECIFIED
Shakiba, E.UNSPECIFIED
Mozaffari, H. R.UNSPECIFIED
Tavilani, H.UNSPECIFIED
Pourmotabbed, T.UNSPECIFIED
Keywords: Glutathione s-transferase hemodialysis polymorphism end stage renal disease malondialdehyde glutathione s-transferases chronic kidney-disease oxidative stress lipoprotein metabolism gene polymorphism t1 m1 susceptibility hemodialysis genotypes Urology & Nephrology
Divisions:
Page Range: pp. 1455-1461
Journal or Publication Title: Renal Failure
Journal Index: ISI
Volume: 38
Number: 9
Identification Number: https://doi.org/10.1080/0886022x.2016.1214054
ISSN: 0886-022X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/416

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