Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Resistance Training Enhances Renal Function in Experimental Renal Ischemia-Reperfusion

Fri May 24 11:08:11 2024

(2021) Resistance Training Enhances Renal Function in Experimental Renal Ischemia-Reperfusion. Sport and Exercise Medicine Switzerland Journal. ISSN 26736640 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Acute kidney injury (AKI) resulting from ischemia-reperfusion injury (IRI) is among the most common complications in hospitalized patients. In recent years, it has been argued that exercise is an approach to attenuate impairments caused by AKI. The purpose of this study was to investigate whether eight weeks of resistance training (RT) has protective effects on IRI. Thirty male Wistar rats (210-230 g) were randomly divided into four groups, including RT+ISC (n=7), RT (n=8), ISC (n=7), and sham (n=8). Animals underwent eight weeks of RT, and 48 hours after the last training session, ischemia (45 min) reperfusion (24 h) was induced. Then animals were sacrificed, and blood and kidney tissue samples were collected to measure creatinine (Cr), blood urea nitrogen (BUN), kidney tissue damage score (KTDS), and kidney weight (KW). The results showed that IRI caused a significant increase in Cr, BUN, KTDS, and KW (p-value <0.05), while RT decreased the severity of KTDS, Cr, and BUN remarkably. (p≤0.05). RT, however, did not attenuate KW (p≤0.05). Overall, the findings of our study provide evidence that RT can attenuate IRI-induced AKI considering enhanced biomarkers; However, further research should be conducted to make certain about the protective effects of exercise training, especially RT. © 2021 Fordham Law Review. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Mina, K.UNSPECIFIED
Abdolhossein, P.UNSPECIFIED
Reza, K. M.UNSPECIFIED
Beat, K.UNSPECIFIED
Divisions:
Journal or Publication Title: Sport and Exercise Medicine Switzerland Journal
Journal Index: Scopus
Volume: 69
Number: 4
Identification Number: https://doi.org/10.34045/SEMS/2021/33
ISSN: 26736640 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4155

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