Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

GFAP and Neuron Specific Enolase (NSE) in the Serum of Suicide Attempters

Fri Jun 2 21:53:39 2023

(2022) GFAP and Neuron Specific Enolase (NSE) in the Serum of Suicide Attempters. Medical Journal of the Islamic Republic of Iran. ISSN 10161430 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: To determine whether neuronal damage and/or neuroinflammation exist in the brain of suicide attempters and to find a novel biological biomarker to help distinguishing high risk individuals with suicide behavior, we aimed to measure glial fibrillary acidic protein (GFAP), neuron specific enolase (NSE), and nerve growth factor (NGF) in suicide attempters. Methods: In the present case-control study, the serum level of NSE, GFAP, and NGF were measured quantitatively in 43 suicide attempters and 43 healthy control participants aged 18 to 35 years. Data were analyzed using the nonpaired t test followed by the Mann-Whitney posttest. Results: The mean serum level of NSE and GFAP were significantly higher in suicide attempters compared with healthy control individuals (p = 0.003, p = 0.001, respectively), while no significant difference was detected in NGF serum level between the 2 groups. Conclusion: Our findings of increased level of NSE along with the significant increase in GFAP would propose the presence of low grade neuroinflammation in the brain of these participants. NSE/GFAP might be good markers that is easily accessible and can be considered as prognostic markers in high-risk suicide attempters © Iran University of Medical Sciences

Item Type: Article
Creators:
CreatorsEmail
Bagheri, M.UNSPECIFIED
Ghaneialvar, H.UNSPECIFIED
Oshnokhah, M.UNSPECIFIED
Salari, S.UNSPECIFIED
Keywords: Gfap Neuronal inflammation Ngf Nse Suicide risk
Divisions:
Journal or Publication Title: Medical Journal of the Islamic Republic of Iran
Journal Index: Scopus
Volume: 36
Number: 1
Identification Number: https://doi.org/10.47176/mjiri.36.103
ISSN: 10161430 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4138

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