Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Gut Microbiota Modification via Glucagon-like Peptide-1 with Beneficial Neuroprotective Effects

Thu Jul 25 18:36:35 2024

(2022) Gut Microbiota Modification via Glucagon-like Peptide-1 with Beneficial Neuroprotective Effects. Middle East Journal of Digestive Diseases. pp. 235-243. ISSN 20085230 (ISSN)

Full text not available from this repository.

Official URL:


BACKGROUND: In recent decades, it has been shown that the association between intestinal bacterial imbalance (dysbiosis) and various diseases such as type 2 diabetes can play a role in the development of Alzheimer's and Parkinson's diseases. In this study, the beneficial effects of intestinal microbiota glucagon-like peptide 1 (GLP-1) in cognitive disorders were investigated. METHODS: PubMed-Medline, Web of Science, and Scopus were searched to identify experimental studies based on the bacterial strains along with GLP-1 1 expression in preventing or reducing cognitive impairment. Of the 233 studies, six were eligible for inclusion, and the Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) risk of bias tool was used to evaluate the risk of bias in individual studies. RESULTS: The results showed that intestinal expression of GLP-1 1 could reduce the intestinal pathogenic genus such as Enterobacteriaceae and was obviously associated with a greater number of beneficial genera such as Lactobacillus and Akkermansia. Also, the neuroprotective effects of Clostridium butyricum with GLP-1 1 in a mice were approved. Therefore, the modulation of the intestinal microbiota, mediated by an increase in the intestinal GLP-1 1 level, consequently improved cognitive function. CONCLUSION: In this review, we have indicated that the gut microbiota, by stimulating the expression of the intestinal hormones like GLP-1 1, and also with a beneficial effect in inhibiting some involved genes in inflammation, can declined the development of cognitive disorders. © 2022, Shiraz University of Medical Sciences. All rights reserved.

Item Type: Article
Mohamadkhani, A.UNSPECIFIED
Mohammadkhani, M. A.UNSPECIFIED
Keywords: Alzheimer disease Gastrointestinal microbiome Glucagon-like peptide 1 Neurodegenerative diseases Parkinson disease cyclooxygenase 2 glucagon like peptide 1 incretin interleukin 1 interleukin 1beta lipopolysaccharide occludin prebiotic agent toll like receptor 4 tumor necrosis factor tyrosine 3 monooxygenase Akkermansia autoimmunity bacterial strain Bacteroides Bifidobacterium bipolar disorder bradykinesia Campylobacter jejuni Clostridium butyricum cognition cognitive defect degenerative disease DNA extraction dysbiosis Enterobacteriaceae enzyme linked immunosorbent assay gene expression health promotion human immunohistochemistry inflammation innate immunity intestine flora Lactobacillus lifestyle modification Medline microglia Morris water maze test mouse nerve cell plasticity nerve degeneration nervous system inflammation neuroprotection non insulin dependent diabetes mellitus nonhuman novel object recognition test open field test quality control Review schizophrenia Scopus spatial learning Streptococcus thermophilus systematic review Web of Science Western blotting
Page Range: pp. 235-243
Journal or Publication Title: Middle East Journal of Digestive Diseases
Journal Index: Scopus
Volume: 14
Number: 2
Identification Number:
ISSN: 20085230 (ISSN)
Depositing User: مهندس مهدی شریفی

Actions (login required)

View Item View Item