Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Hypo-and Hyperphosphatemia at Admission as Independent Factors in the Mortality of COVID-19 Patients: Findings from a Retrospective Cohort Study

Wed Feb 8 09:46:25 2023

(2022) Hypo-and Hyperphosphatemia at Admission as Independent Factors in the Mortality of COVID-19 Patients: Findings from a Retrospective Cohort Study. International Journal of Endocrinology and Metabolism. ISSN 1726913X (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: Electrolyte imbalances are common in COVID-19 infection and are associated with poor outcomes in hospitalized patients. Objectives: This study examined whether serum phosphate imbalances at admission are associated with mortality in hospitalized COVID-19 patients. Methods: In this registry-based single-center retrospective cohort study, 1349 inpatients with COVID-19 were included from March 2020 to March 2021 in an academic hospital in Ilam (southwest Iran). The Cox proportional hazard (PH) regression model was ap-plied to the data set of COVID-19. Results: The in-hospital median survival time for patients with low, normal, and high serum phosphate levels was 14, 25, and 8 days, respectively. In a multivariate model, adjusted for the other variables, patients with hypophosphatemia (adjusted hazard ratio HR, 2.53; 95% CI, 1.15-5.58; P = 0.02) and hyperphosphatemia (adjusted HR, 1.77; 95% CI, 1.00-3.14; P = 0.05) had an increased mortality hazard compared with those who had normal levels of serum phosphate. Conclusions: Our results demonstrate a strong effect of hypophosphatemia and hyperphosphatemia with increased in-hospital mortality in COVID-19 patients. Intensive medical care and more attention must be paid to COVID-19 patients with serum phosphate imbalances at admission. © 2022, International Journal of Endocrinology and Metabolism.

Item Type: Article
Creators:
CreatorsEmail
Hadavi, M.UNSPECIFIED
Taghinezhad, F.UNSPECIFIED
Shafiei, E.UNSPECIFIED
Babakr, S. H.UNSPECIFIED
Bastaminejad, S.UNSPECIFIED
Kaffashian, M.UNSPECIFIED
Ahmadi, I.UNSPECIFIED
Mozafari, A.UNSPECIFIED
Keywords: COVID-19 Hyperphosphatemia Hypophosphatemia In-Hospital Mortality SARS-CoV-2 phosphate aged Article cohort analysis coronavirus disease 2019 female hospital admission hospital patient human Iran major clinical study male median survival time mortality phosphate blood level retrospective study university hospital
Divisions:
Journal or Publication Title: International Journal of Endocrinology and Metabolism
Journal Index: Scopus
Volume: 20
Number: 3
Identification Number: https://doi.org/10.5812/ijem-126386
ISSN: 1726913X (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4112

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