Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A Retrospective Cohort Study of SARS-CoV-2 Mortality Rate in Individuals with Opioid Use Disorder in Ilam (Southwest of Iran)

Tue Jun 25 07:07:19 2024

(2022) A Retrospective Cohort Study of SARS-CoV-2 Mortality Rate in Individuals with Opioid Use Disorder in Ilam (Southwest of Iran). Journal of Advances in Medical and Biomedical Research. pp. 452-457. ISSN 26766264 (ISSN)

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Background & Objective: Individuals with opioid use disorder are a marginalized population in any society. They commonly have a weaker immune system, greater stress vulnerability, poorer health, more high-risk behaviors, and less access to healthcare services compared to the general population, which can expose them to a risk of severe COVID-19 complications. This study aimed to evaluate the effects of opioid use disorder on mortality in patients with SARS-CoV-2. Materials & Methods: This registry-based retrospective cohort study was conducted on 2362 consecutive inpatients with a confirmed diagnosis of SARS-CoV-2 between March 5, 2020 and March 21, 2021, presenting to a university hospital in Ilam in the southwest of Iran. Forty-five patients with opioid use disorder were identified in this study and matched to 100 patients without opium addiction. All patients with a history of opium addiction were included in the study group, and age-and sex-matched patients without opioid use disorder were randomly recruited as the controls. After adjusting for the effects of age and comorbidities, data were analyzed in STATA version 10, using logistic regression models. Results: The mortality of patients with opioid use disorder increased following COVID-19 (adjusted OR: 6.59; 95 CI: 1.84–23.59; P=0.004). Hypertension (adjusted OR: 8.17; 95 CI: 2.21–30.15; P=0.002) and advancing age (OR: 1.06; 95 CI: 1.01–1.11; P=0.01) were significantly associated with increased COVID-19 mortality. Conclusion: Based on the present findings, opioid use disorder is a possible risk factor for mortality following COVID-19. The findings of the present study can be applied in the implementation of preventive measures and policies and prioritization of COVID-19 vaccination. However, further relevant research is recommended. © 2022, Zanjan University of Medical Sciences and Health Services. All rights reserved.

Item Type: Article
Taghinezhad, F.UNSPECIFIED
Khalafzadeh, A.UNSPECIFIED
Keywords: COVID-19 Mortality Opioid use disorder Opioids adult Article body mass cardiovascular disease chronic kidney failure chronic lung disease cigarette smoking cohort analysis comorbidity coronavirus disease 2019 diabetes mellitus female human hypertension major clinical study male malignant neoplasm marriage mortality rate opiate addiction retrospective study
Page Range: pp. 452-457
Journal or Publication Title: Journal of Advances in Medical and Biomedical Research
Journal Index: Scopus
Volume: 30
Number: 142
Identification Number:
ISSN: 26766264 (ISSN)
Depositing User: مهندس مهدی شریفی

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