Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Comparing the COVID-19 Mortality Rate in Cancer Patients with and Without a History of Chemotherapy

Thu Feb 2 18:43:45 2023

(2022) Comparing the COVID-19 Mortality Rate in Cancer Patients with and Without a History of Chemotherapy. International Journal of Cancer Management. ISSN 25384422 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background: Patients with cancer are potentially vulnerable to COVID-19 infection due to the immune-compromised state of cancer or its treatment complications. Objectives: This study compared the COVID-19 mortality rate in cancer patients with and without a history of chemotherapy. Methods: This registry-based cohort study launched from March 2020 to March 2021 contains 2350 records in which 64 COVID-19 patients with cancer were included, of which 27 patients underwent the chemotherapy plan within eight weeks before confirmed COVID-19. In addition, age and sex were matched in patients without a history of cancer as a control group. Two groups of cancer patients with and without a history of chemotherapy compared to the control group using cox proportional hazard regression models in Stata.10 software. Results: Patients with cancer had a higher hazard for in-hospital mortality from COVID-19 infection (adjusted HR; 2.27, 95 CI: 1.25-4.13, P = 0.007) after adjusting for age, sex, body mass index (BMI), and co-morbidities. Our result showed no significant association between chemotherapy and control groups (adjusted HR; 1.65, 95 CI: 0.60-4.56, P = 0.33). Conclusions: Patients with cancer faced a risk of mortality from COVID-19 two times higher than those without cancer. However, chemotherapy did not increase the mortality following COVID-19 infection. © 2022, Author(s).

Item Type: Article
Creators:
CreatorsEmail
Bazgir, N.UNSPECIFIED
Taghinezhad, F.UNSPECIFIED
Nourmohammadi, H.UNSPECIFIED
Azami, G.UNSPECIFIED
Ahmadi, I.UNSPECIFIED
Mozafari, A.UNSPECIFIED
Keywords: Chemotherapy COVID-19 Drug Therapy Neoplasm SARS-CoV-2 Infection
Divisions:
Journal or Publication Title: International Journal of Cancer Management
Journal Index: Scopus
Volume: 15
Number: 10
Identification Number: https://doi.org/10.5812/ijcm-128404
ISSN: 25384422 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4102

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