Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Therapeutic Effects of Aloe vera (L.) Burm.f. and Vitis vinifera L. Combination Cream on Wound Healing in Second-Degree Burn Model in Rats: Quantification of Compounds and VEGF & TGFβ Gene Expression

Mon Jul 15 19:08:46 2024

(2022) Therapeutic Effects of Aloe vera (L.) Burm.f. and Vitis vinifera L. Combination Cream on Wound Healing in Second-Degree Burn Model in Rats: Quantification of Compounds and VEGF & TGFβ Gene Expression. Traditional and Integrative Medicine. pp. 52-63. ISSN 24765104 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Finding more efficient agents with fewer side effects for the treatment of burns has been a concern for researchers. The current study aims to assess Aloe vera (L.) Burm.f. and Vitis vinifera L. extract combination (AVEC) effects on wound healing in rats compared with silver sulfadiazine (SSD). Identification of individual polyphenols of the plant extracts was performed by HPLC. The animals were randomly divided into twelve groups. Standard second-degree burn wounds were induced on the back. Groups were treated with Aloe vera (A.V) and Vitis vinifera (V.V) creams at concentrations of 0.5, 1, 1.5, and 2 with ED50 values of 1.5 ± 0.02 and 1.4 ± 0.08 , respectively. The other group was treated with an AVEC cream (1.5). The samples of burned skin tissue were collected from the rats for histopathological examination. To evaluate the expression of VEGF and TGFβ1, the real time-PCR method was used. Kaempferol was only detected in Aloe. This study revealed that AVEC cream exhibits significant wound healing activity. VEGF and TGFβ1 had a significant increase in the AVEC. Based on our findings, AVEC cream can be a therapy of choice for burn injuries. Copyright © 2022 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences.

Item Type: Article
Creators:
CreatorsEmail
Moayeri, A.UNSPECIFIED
Ramz, K.UNSPECIFIED
Karimi, E.UNSPECIFIED
Azizi, M.UNSPECIFIED
Abbasi, N.UNSPECIFIED
Aidy, A.UNSPECIFIED
Bahmani, M.UNSPECIFIED
Keywords: Aloe vera High performance liquid chromatography (HPLC) Second-degree burns Vascular endothelial growth factor(VEGF) Vitis vinifera
Divisions:
Page Range: pp. 52-63
Journal or Publication Title: Traditional and Integrative Medicine
Journal Index: Scopus
Volume: 7
Number: 1
Identification Number: https://doi.org/10.18502/tim.v7i1.9063
ISSN: 24765104 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4099

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