Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A Comprehensive Review of the Protein Subunit Vaccines Against COVID-19

Thu Feb 2 18:57:23 2023

(2022) A Comprehensive Review of the Protein Subunit Vaccines Against COVID-19. Frontiers in microbiology. p. 927306. ISSN 1664-302X (Print) 1664-302X (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/35910658

Abstract

Two years after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), in December 2019, the first infections were identified in Wuhan city of China. SARS-CoV-2 infection caused a global pandemic and accordingly, 5.41 million deaths worldwide. Hence, developing a safe and efficient vaccine for coronavirus disease 2019 (COVID-19) seems to be an urgent need. Attempts to produce efficient vaccines inexhaustibly are ongoing. At present time, according to the COVID-19 vaccine tracker and landscape provided by World Health Organization (WHO), there are 161 vaccine candidates in different clinical phases all over the world. In between, protein subunit vaccines are types of vaccines that contain a viral protein like spike protein or its segment as the antigen assumed to elicit humoral and cellular immunity and good protective effects. Previously, this technology of vaccine manufacturing was used in a recombinant influenza vaccine (RIV4). In the present work, we review protein subunit vaccines passing their phase 3 and 4 clinical trials, population participated in these trials, vaccines manufactures, vaccines efficiency and their side effects, and other features of these vaccines.

Item Type: Article
Creators:
CreatorsEmail
Heidary, M.UNSPECIFIED
Kaviar, V. H.UNSPECIFIED
Shirani, M.UNSPECIFIED
Ghanavati, R.UNSPECIFIED
Motahar, M.UNSPECIFIED
Sholeh, M.UNSPECIFIED
Ghahramanpour, H.UNSPECIFIED
Khoshnood, S.UNSPECIFIED
Keywords: Covid-19 SARS-CoV-2 protein subunit review vaccine commercial or financial relationships that could be construed as a potential conflict of interest.
Divisions:
Page Range: p. 927306
Journal or Publication Title: Frontiers in microbiology
Journal Index: Pubmed
Volume: 13
Identification Number: https://doi.org/10.3389/fmicb.2022.927306
ISSN: 1664-302X (Print) 1664-302X (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4077

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