Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The effects of nutrition bio-shield superfood powder on immune system function: A clinical trial study among patients with COVID-19

Wed Feb 8 09:53:14 2023

(2022) The effects of nutrition bio-shield superfood powder on immune system function: A clinical trial study among patients with COVID-19. Frontiers in immunology. p. 919402. ISSN 1664-3224 (Electronic) 1664-3224 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/36091037

Abstract

The present study aimed to evaluate the effects of Nutrition Bio-shield Superfood (NBS) powder on the immune system function and clinical manifestations in patients with COVID-19. We compare the effects of NBS powder on the immune system function and clinical manifestations among two different groups: 1) intervention group receiving standard treatment scheduled according to treatment guidelines plus NBS powder, and 2) control group receiving only the same standard treatment. The serum levels of IL-2, IL-6, IL-17, IFNgamma, and TNFalpha were determined after four weeks of treatment by specific ELISA kits according to the manufacturer's instructions. Finally, the level of immune system stimulation and inflammatory markers were compared at baseline and after intervention in both groups. Data were analyzed using SPSS (version 22). A p-value of </= 0.05 was set as significant. A total of 47 patients with COVID-19 (24 patients in the intervention group and 23 patients in the control group) were included in this study. Results showed that the differences in the mean decrease of IL-2, IL-6, and TNF-alpha in the intervention group in comparison to the control group were 0.93, 10.28, and 8.11 pg/ml, respectively (P<0.001). On the other hand, there was no difference in IL-17, IFNgamma, monocytes, eosinophil, and other inflammatory indices between the intervention and control groups. Although NBS powder was able to significantly decrease the levels of some proinflammatory cytokines in patients with COVID-19, however, it is noteworthy that the course of the disease was to large part unaffected by NBS power and there was a reduction independent of treatment. The present study indicates that NBS powder could provide a beneficial anti-inflammatory effect in patients with COVID-19. Hence, NBS in treating patients with COVID-19 shows promise as an adjuvant to the current standard antiviral treatment of such patients. Clinical Trial Registration: https://www.irct.ir, identifier IRCT20200426047206N1.

Item Type: Article
Creators:
CreatorsEmail
Azizi Jalilian, F.UNSPECIFIED
Keshavarz, G.UNSPECIFIED
Khazaei, S.UNSPECIFIED
Nezamdoost, M.UNSPECIFIED
Hashemi, S. H.UNSPECIFIED
Mamani, M.UNSPECIFIED
Ansari, N.UNSPECIFIED
Amini, R.UNSPECIFIED
Khalkhali, A.UNSPECIFIED
Keshavarz, A.UNSPECIFIED
Ayubi, E.UNSPECIFIED
Fazeli, M.UNSPECIFIED
Heidari Moghadam, R.UNSPECIFIED
Alizadeh, S.UNSPECIFIED
Pourhossein, B.UNSPECIFIED
Teimouri, A.UNSPECIFIED
Keramat, F.UNSPECIFIED
Karampour, S.UNSPECIFIED
Khakzad, M.UNSPECIFIED
Keywords: *COVID-19/drug therapy Humans *Interleukin-17 Interleukin-2 Interleukin-6 Monocytes Powders Tumor Necrosis Factor-alpha Covid-19 ELISA - enzyme-linked immunosorbent assay Iran immunity system function nutrition bio-safety powder commercial or financial relationships that could be construed as a potential conflict of interest.
Divisions:
Page Range: p. 919402
Journal or Publication Title: Frontiers in immunology
Journal Index: Pubmed
Volume: 13
Identification Number: https://doi.org/10.3389/fimmu.2022.919402
ISSN: 1664-3224 (Electronic) 1664-3224 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4067

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