Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019

Sun Jan 29 19:24:41 2023

(2022) The global burden of cancer attributable to risk factors, 2010-19: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. pp. 563-591. ISSN 0140-6736

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Abstract

Background Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. Methods The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. Findings Globally, in 2019, the risk factors included in this analysis accounted for 4.45 million (95 uncertainty interval 4.01-4.94) deaths and 105 million (95.0-116) DALYs for both sexes combined, representing 44.4 (41.3-48.4) of all cancer deaths and 42.0 (39.1-45.6) of all DALYs. There were 2.88 million (2.60-3.18) risk-attributable cancer deaths in males (50.6 47.8-54.1 of all male cancer deaths) and 1.58 million (1.36-1.84) risk-attributable cancer deaths in females (36.3% 32.5-41.3 of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20.4% (12.6-28.4) and DALYs by 16.8% (8.8-25.0), with the greatest percentage increase in metabolic risks (34.7% 27.9-42.8 and 33.3% 25.8-42.0). Interpretation The leading risk factors contributing to global cancer burden in 2019 were behavioural, whereas metabolic risk factors saw the largest increases between 2010 and 2019. Reducing exposure to these modifiable risk factors would decrease cancer mortality and DALY rates worldwide, and policies should be tailored appropriately to local cancer risk factor burden. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.

Item Type: Article
Creators:
CreatorsEmail
Tran, K. B.UNSPECIFIED
Lang, J. J.UNSPECIFIED
Compton, K.UNSPECIFIED
Xu, R. X.UNSPECIFIED
Acheson, A. R.UNSPECIFIED
Henrikson, H. J.UNSPECIFIED
Kocarnik, J. M.UNSPECIFIED
Penberthy, L.UNSPECIFIED
Aali, A.UNSPECIFIED
Abbas, Q.UNSPECIFIED
Abbasi, B.UNSPECIFIED
Abbasi-Kangevari, M.UNSPECIFIED
Abbasi-Kangevari, Z.UNSPECIFIED
Abbastabar, H.UNSPECIFIED
Abdelmasseh, M.UNSPECIFIED
Abd-Elsalam, S.UNSPECIFIED
Abdelwahab, A. A.UNSPECIFIED
Abdoli, G.UNSPECIFIED
Abdulkadir, H. A.UNSPECIFIED
Abedi, A.UNSPECIFIED
Abegaz, K. H.UNSPECIFIED
Abidi, H.UNSPECIFIED
Aboagye, R. G.UNSPECIFIED
Abolhassani, H.UNSPECIFIED
Absalan, A.UNSPECIFIED
Abtew, Y. D.UNSPECIFIED
Ali, H. A.UNSPECIFIED
Abu-Gharbieh, E.UNSPECIFIED
Achappa, B.UNSPECIFIED
Acuna, J. M.UNSPECIFIED
Addison, D.UNSPECIFIED
Addo, I. Y.UNSPECIFIED
Adegboye, O. A.UNSPECIFIED
Adesina, M. A.UNSPECIFIED
Adnan, M.UNSPECIFIED
Adnani, Q. E. S.UNSPECIFIED
Advani, S. M.UNSPECIFIED
Afrin, S.UNSPECIFIED
Afzal, M. S.UNSPECIFIED
Aggarwal, M.UNSPECIFIED
Ahinkorah, B. O.UNSPECIFIED
Ahmad, A. R.UNSPECIFIED
Ahmad, R.UNSPECIFIED
Ahmad, S.UNSPECIFIED
Ahmadi, S.UNSPECIFIED
Ahmed, H.UNSPECIFIED
Ahmed, L. A.UNSPECIFIED
Ahmed, M. B.UNSPECIFIED
Rashid, T. A.UNSPECIFIED
Aiman, W.UNSPECIFIED
Ajami, M.UNSPECIFIED
Akalu, G. T.UNSPECIFIED
Akbarzadeh-Khiavi, M.UNSPECIFIED
Aklilu, A.UNSPECIFIED
Akonde, M.UNSPECIFIED
Akunna, C. J.UNSPECIFIED
Al Hamad, H.UNSPECIFIED
Alahdab, F.UNSPECIFIED
Alanezi, F. M.UNSPECIFIED
Alanzi, T. M.UNSPECIFIED
Alessy, S. A.UNSPECIFIED
Algammal, A. M.UNSPECIFIED
Al-Hanawi, M. K.UNSPECIFIED
Alhassan, R. K.UNSPECIFIED
Ali, B. A.UNSPECIFIED
Ali, L.UNSPECIFIED
Ali, S. S.UNSPECIFIED
Alimohamadi, Y.UNSPECIFIED
Alipour, V.UNSPECIFIED
Aljunid, S. M.UNSPECIFIED
Alkhayyat, M.UNSPECIFIED
Al-Maweri, S. A. A.UNSPECIFIED
Almustanyir, S.UNSPECIFIED
Alonso, N.UNSPECIFIED
Alqalyoobi, S.UNSPECIFIED
Al-Raddadi, R. M.UNSPECIFIED
Al-Rifai, R. H. H.UNSPECIFIED
Al-Sabah, S. K.UNSPECIFIED
Al-Tammemi, A. B.UNSPECIFIED
Altawalah, H.UNSPECIFIED
Alvis-Guzman, N.UNSPECIFIED
Amare, F.UNSPECIFIED
Ameyaw, E. K.UNSPECIFIED
Dehkordi, J. J. A.UNSPECIFIED
Amirzade-Iranaq, M. H.UNSPECIFIED
Amu, H.UNSPECIFIED
Amusa, G. A.UNSPECIFIED
Ancuceanu, R.UNSPECIFIED
Anderson, J. A.UNSPECIFIED
Animut, Y. A.UNSPECIFIED
Anoushiravani, A.UNSPECIFIED
Anoushirvani, A. A.UNSPECIFIED
Ansari-Moghaddam, A.UNSPECIFIED
Ansha, M. G.UNSPECIFIED
Antony, B.UNSPECIFIED
Antwi, M. H.UNSPECIFIED
Anwar, S. L.UNSPECIFIED
Anwer, R.UNSPECIFIED
Anyasodor, A. E.UNSPECIFIED
Arabloo, J.UNSPECIFIED
othersUNSPECIFIED
Keywords: social determinants life-style health covid-19 obesity deaths uk General & Internal Medicine
Divisions:
Page Range: pp. 563-591
Journal or Publication Title: Lancet
Journal Index: ISI
Volume: 400
Number: 10352
ISSN: 0140-6736
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4053

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