Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Comparing the expression levels of tripartite motif containing 28 in mild and severe COVID-19 infection

Thu Feb 2 17:18:59 2023

(2022) Comparing the expression levels of tripartite motif containing 28 in mild and severe COVID-19 infection. Virology Journal. p. 7.

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Abstract

Background Tripartite motif-containing 28 (TRIM28) is an impressive regulator of the epigenetic control of the antiviral immune response. This study evaluated if the differential expression of TRIM28 correlates with the severity of coronavirus disease 2019 (COVID-19) infection. Methods A total of 330 COVID-19 patients, including 188 mild and 142 severe infections, and 160 healthy controls were enrolled in this study. Quantitative real-time polymerase chain reaction (qPCR) was used to determine the expression levels of TRIM28 in the studied patients. Results TRIM28 mRNA levels were significantly lower in both groups of patients versus the control group and in the severe group indicated further reduction in comparison to mild infection. The multivariate logistic regression analysis showed the mean age, lower levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol, lower 25-hydroxyvitamin D, and PCR cycle threshold (Ct) value and higher levels of erythrocyte sedimentation rate (ESR) and differential expression of TRIM28 were linked to the severity of COVID-19 infection. Conclusion The results of this study proved that the downregulation of TRIM28 might be associated with the severity of COVID-19 infection. Further studies are required to determine the association between the COVID-19 infection severity and TRIM family proteins.

Item Type: Article
Creators:
CreatorsEmail
Tavakoli, R.UNSPECIFIED
Rahimi, P.UNSPECIFIED
Hamidi-Fard, M.UNSPECIFIED
Eaybpoush, S.UNSPECIFIED
Doroud, D.UNSPECIFIED
Ahmadi, I.UNSPECIFIED
Anvari, E.UNSPECIFIED
Aghasadeghi, M.UNSPECIFIED
Fateh, A.UNSPECIFIED
Keywords: Tripartite motif containing 28 Coronavirus disease 2019 Mild infection Severe infection trim family proteins recognition Virology
Divisions:
Page Range: p. 7
Journal or Publication Title: Virology Journal
Journal Index: ISI
Volume: 19
Number: 1
Identification Number: https://doi.org/10.1186/s12985-022-01885-0
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4041

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