Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Anhedonia symptoms: The assessment of brain functional mechanism following music stimuli using functional magnetic resonance imaging

Sat Jun 10 14:33:22 2023

(2022) Anhedonia symptoms: The assessment of brain functional mechanism following music stimuli using functional magnetic resonance imaging. Psychiatry Research-Neuroimaging. p. 11. ISSN 0925-4927

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Abstract

Purpose: This study aimed to investigate the effect of music stimulation on the brain functional mechanism of depressed patients with anhedonia symptoms using functional magnetic resonance imaging (fMRI). Methods: Participants in this study included 20 healthy subjects as the control group, 25 subjects with depression and no anhedonia as the intervention group A, and 24 subjects with depression and anhedonia as the inter-vention group B. The safely emotional stimulation was done by Iranian music. To investigate the effect of music therapy on the brain, a task including 50 tracks of 12 s Iranian music (traditional and pop) was used. Finally, the data were analyzed using SPM Toolbox in MATLAB software. Results: The results showed that brain patterns in depressed patients with and without anhedonia could be distinguished based on positive and negative musical stimuli (p < 0.05). Important fMRI biomarker such as effective connectivity strength related to the fronto-limbic network, including the supragenual ACC, subgenual ACC, AMYG, and FFG were evaluated in depressed patients with anhedonia. Conclusion: This was the first study to investigate the neural circuits involved in music-related emotional pro-cessing in patients with anhedonia symptoms. These findings could help advance neurological understandings of anhedonia and suggest new treatments.

Item Type: Article
Creators:
CreatorsEmail
Faramarzi, A.UNSPECIFIED
Sharini, H.UNSPECIFIED
Shanbehzadeh, M.UNSPECIFIED
Pour, M. Y.UNSPECIFIED
Fooladi, M.UNSPECIFIED
Jalalvandi, M.UNSPECIFIED
Amiri, S.UNSPECIFIED
Kazemi-Arpanahi, H.UNSPECIFIED
Keywords: FMRI Anhedonia Fronto-limbic network Effective connectivity Brain mapping anterior cingulate cortex major depressive disorder amygdala therapy fmri Neurosciences & Neurology Psychiatry
Divisions:
Page Range: p. 11
Journal or Publication Title: Psychiatry Research-Neuroimaging
Journal Index: ISI
Volume: 326
Identification Number: https://doi.org/10.1016/j.pscychresns.2022.111532
ISSN: 0925-4927
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4039

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