Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Antibacterial activity of recently approved antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) strains: A systematic review and meta-analysis

Wed Feb 8 10:50:31 2023

(2022) Antibacterial activity of recently approved antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) strains: A systematic review and meta-analysis. Annals of Clinical Microbiology and Antimicrobials. p. 12.

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Abstract

Background Methicillin-resistant Staphylococcus aureus (MRSA) infections are considered an important public health problem, and treatment options are limited. Accordingly, in this meta-analysis, we analyzed published studies to survey in vitro activity of recently approved antibiotics against MRSA isolates. Methods We searched electronic databases; PubMed, Scopus, and Web of Science to identify relevant studies (until November 30, 2020) that have focused on the in vitro activity of telavancin, dalbavancin, oritavancin, and tedizolid against MRSA isolates. Statistical analyses were conducted using STATA software (version 14.0). Results Thirty-eight studies were included in this meta-analysis. Overall in vitro activity of tedizolid on 12,204 MRSA isolates was 0.250 and 0.5 mu g/mL for MIC50 and MIC90, (minimum inhibitory concentration at which 50 and 90 of isolates were inhibited, respectively), respectively. The overall antibacterial activity of dalbavancin on 28539 MRSA isolates was 0.060 and 0.120 mu g/mL for MIC50 and MIC90, respectively. The overall antibacterial activity of oritavancin on 420 MRSA isolates was 0.045 and 0.120 mu g/mL for MIC50 and MIC90, respectively. The overall antibacterial activity of telavancin on 7353 MRSA isolates was 0.032 and 0.060 mu g/mL for MIC50 and MIC90, respectively. The pooled prevalence of tedizolid, telavancin, and dalbavancin susceptibility was 100 (95 CI: 100-100). Conclusion Telavancin, dalbavancin, oritavancin, and tedizolid had potent in vitro activity against MRSA isolates. The low MICs and high susceptibility rates of these antibiotics recommend a hopeful direction to introduce useful antibiotics in treating MRSA infections in the future.

Item Type: Article
Creators:
CreatorsEmail
Liu, F.UNSPECIFIED
Rajabi, S.UNSPECIFIED
Shi, C. H.UNSPECIFIED
Afifirad, G.UNSPECIFIED
Omidi, N.UNSPECIFIED
Kouhsari, E.UNSPECIFIED
Khoshnood, S.UNSPECIFIED
Azizian, K.UNSPECIFIED
Keywords: MRSA Antibacterial activity Tedizolid Telavancin Dalbavancin Oritavancin Lipoglycopeptide in-vitro activity gram-positive pathogens skin-structure infections hospital-acquired pneumonia broth microdilution method latin-american countries acute bacterial skin antimicrobial agents tedizolid activity comparator agents Microbiology
Divisions:
Page Range: p. 12
Journal or Publication Title: Annals of Clinical Microbiology and Antimicrobials
Journal Index: ISI
Volume: 21
Number: 1
Identification Number: https://doi.org/10.1186/s12941-022-00529-z
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4033

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