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Repository of Research and Investigative Information

Ilam University of Medical Sciences

The role of heat shock proteins in metastatic colorectal cancer: A review

Wed Feb 21 01:49:41 2024

(UNSPECIFIED) The role of heat shock proteins in metastatic colorectal cancer: A review. Journal of Cellular Biochemistry. p. 32. ISSN 0730-2312

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Abstract

Heat shock proteins (HSPs) are a large molecular chaperone family classified by their molecular weights, including HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110. HSPs are likely to have antiapoptotic properties and participate actively in various processes such as tumor cell proliferation, invasion, metastases, and death. In this review, we discuss comprehensively the functions of HSPs associated with the progression of colorectal cancer (CRC) and metastasis and resistance to cancer therapy. Taken together, HSPs have numerous clinical applications as biomarkers for cancer diagnosis and prognosis and potential therapeutic targets for CRC and its related metastases.

Item Type: Article
Creators:
CreatorsEmail
Javid, H.UNSPECIFIED
Hashemian, P.UNSPECIFIED
Yazdani, S.UNSPECIFIED
Mashhad, A. S.UNSPECIFIED
Karimi-Shahri, M.UNSPECIFIED
Keywords: colorectal cancer (CRC) heat shock proteins (HSPs) metastatic colorectal cancer alpha-b-crystallin epithelial-mesenchymal transition endothelial growth-factor colon-cancer beta-catenin tumor-suppressor therapeutic target breast-cancer cell-cycle heat-shock-protein-60 hsp60 Biochemistry & Molecular Biology Cell Biology
Divisions:
Page Range: p. 32
Journal or Publication Title: Journal of Cellular Biochemistry
Journal Index: ISI
Identification Number: https://doi.org/10.1002/jcb.30326
ISSN: 0730-2312
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4028

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