Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Nephroprotective activity of naringin against chemical-induced toxicity and renal ischemia/reperfusion injury: A review

Mon May 27 06:55:03 2024

(2022) Nephroprotective activity of naringin against chemical-induced toxicity and renal ischemia/reperfusion injury: A review. Avicenna Journal of Phytomedicine. p. 14. ISSN 2228-7930

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Objective: The kidney is well-known as the vital organ which is responsible for maintaining body homeostasis and secretion of toxic metabolites. Renal injury is accompanied by oxidative stress which results in cellular apoptosis, lipid peroxidation, and reduction of antioxidant levels. Plant extracts and their phytoconstituents, owing to free radical scavenging properties, seem to be valuable against modern synthetic and chemical drugs. Naringin is a flavonoid present in citrus fruits with pharmacologic effects including antioxidant, anti-inflammatory, and antiapoptotic properties. This review summarizes the renoprotective effects of naringin and discusses mechanisms of its action against renal injury. Materials and Methods: For this paper, original subject-related articles published up to October 2020 have been reviewed in the databases, including PubMed, Scopus, and Web of Science, and Google Scholar. Results: Naringin increases antioxidant enzyme activity, and glutathione content, reduces lipid peroxidation and inhibits inflammatory cytokines. In the molecular investigation, naringin activates the Nrf-2 signaling, prevents apoptosis signaling, and inhibits the autophagy pathway. Besides, naringin could protect the kidney through modulating microRNA-10a in the kidney tissue in an acute kidney injury model. Conclusion: This review recommends that naringin can be considered a promising candidate to treat kidney dysfunction induced by oxidative stress in the future.

Item Type: Article
Keywords: Kidney Naringin Oxidative stress Toxicity gentamicin-induced nephrotoxicity oxidative stress toxicological evaluation diabetic-nephropathy citrus flavonoids kidney damage rats mechanisms dysfunction cyclosporine Pharmacology & Pharmacy
Page Range: p. 14
Journal or Publication Title: Avicenna Journal of Phytomedicine
Journal Index: ISI
Volume: 12
Number: 4
ISSN: 2228-7930
Depositing User: مهندس مهدی شریفی

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