Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Angiotensin-converting enzyme 2 rs2285666 polymorphism and clinical parameters as the determinants of COVID-19 severity in Iranian population

Sun Jan 29 22:28:01 2023

(2022) Angiotensin-converting enzyme 2 rs2285666 polymorphism and clinical parameters as the determinants of COVID-19 severity in Iranian population. International Journal of Immunogenetics. pp. 325-332. ISSN 1744-3121

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Abstract

Host genetic factors may be correlated with the severity of coronavirus disease 2019 (COVID-19). Angiotensin-converting enzyme 2 (ACE2) plays a vital role in viral cell entrance. The current study aimed to evaluate the association of ACE2 rs2285666 polymorphism and clinical parameters with COVID-19 mortality. The ACE2 rs2285666 polymorphism was genotyped using the polymerase chain reaction-restriction fragment length polymorphism in 556 recovered and 522 dead patients. In this study, the frequency of ACE2 rs2285666 CC was significantly higher than TT genotype in dead patients. The multivariate logistic regression analysis results showed that the higher levels of alanine aminotransferase, alkaline phosphatase, creatinine, erythrocyte sedimentation rate, and C-reactive protein and the low levels of uric acid, cholesterol, low density lipoprotein, 25-hydroxyvitamin D, real-time PCR Ct values, and ACE2 rs2285666 CC genotype were associated with increased mortality rates after COVID-19. In conclusion, our findings demonstrated a possible link between COVID-19 mortality, clinical parameters, and ACE2 rs2285666 CC. Further research is required to confirm these results.

Item Type: Article
Creators:
CreatorsEmail
Khalilzadeh, F.UNSPECIFIED
Sakhaee, F.UNSPECIFIED
Sotoodehnejadnematalahi, F.UNSPECIFIED
Zamani, M. S.UNSPECIFIED
Ahmadi, I.UNSPECIFIED
Anvari, E.UNSPECIFIED
Fateh, A.UNSPECIFIED
Keywords: angiotensin-converting enzyme 2 coronavirus disease 2019 severe acute respiratory syndrome coronavirus 2 coronavirus ace2 Genetics & Heredity Immunology
Divisions:
Page Range: pp. 325-332
Journal or Publication Title: International Journal of Immunogenetics
Journal Index: ISI
Volume: 49
Number: 5
Identification Number: https://doi.org/10.1111/iji.12598
ISSN: 1744-3121
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3999

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