Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Economic Evaluation of Denosumab for Treatment of Postmenopausal Osteoporosis: A Systematic Review

Thu Feb 2 18:09:13 2023

(2022) Economic Evaluation of Denosumab for Treatment of Postmenopausal Osteoporosis: A Systematic Review. Iranian Journal of Public Health. pp. 1502-1512. ISSN 2251-6085

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Abstract

Background: We aimed to review the systematic economic evaluation of denosumab versus than alternative drugs and oral bisphosphonates of postmenopausal osteoporosis in women and help health system policy makers for prioritizing and optimally allocate limited health resources. Methods: We examined the databases of PubMed, Web of Science, Embase, Scopus, Cochrane Library, ProQuest. Strategy search was designed based on keywords. Inclusion criteria were: studies that conducted economic evaluation denosumab compared to oral bisphosphonates for the treatment of osteoporosis in postmenopausal women. Cost-effectiveness studies conducted using decision analysis models based on the economic evaluation approach; studies with available full-text papers; and studies written in English and published between 2010 and 2020. After selecting articles based on inclusion and exclusion criteria, data were extracted and the results were summarized. The quality of the articles was evaluated using the CHEERS checklist. Results: Among 214 initial studies, 8 studies met the inclusion criteria. Most studies focused on the costeffectiveness of denosumab compared with oral bisphosphonates for the treatment of osteoporosis. The study agreed interval ranged from 3 months to 5 years. The costs investigated in the studies were direct medical costs. In most studies, the use of denosumab significantly prevented fractures. Conclusion: Denosumab is generally more cost-effective than alternative drugs and oral bisphosphonates (alendronate, risedronate, strontium ranelate, ibandronate, and untreated).

Item Type: Article
Creators:
CreatorsEmail
Nargesi, S.UNSPECIFIED
Barghazan, S. H.UNSPECIFIED
Sani'ee, N.UNSPECIFIED
Kemmak, A. R.UNSPECIFIED
Keywords: Cost benefit analysis Denosumab Osteoporosis Postmenopausal Systematic review cost-effectiveness oral bisphosphonates women Public, Environmental & Occupational Health
Divisions:
Page Range: pp. 1502-1512
Journal or Publication Title: Iranian Journal of Public Health
Journal Index: ISI
Volume: 51
Number: 7
ISSN: 2251-6085
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3997

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