Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Proposed Pathway Linking Respiratory Infections with Depression

Thu Feb 2 18:16:57 2023

(2022) Proposed Pathway Linking Respiratory Infections with Depression. Clinical Psychopharmacology and Neuroscience. pp. 199-210. ISSN 1738-1088

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Abstract

Depression is one of the most important causes of disability and loss of useful life of people around the world. Acute respiratory infection caused a large number of severe illnesses and deaths of the world and most of these due to viral infections, which is estimated more than 80 of respiratory infections. Detection of viruses by immune pathogen recognition receptors activates the intracellular signaling cascade and eventually cause produces interferons. Inflammatory process begins with secretion of interferons and the expression of interferon-stimulated genes. One of the most important of these genes is indoleamine-pyrrole 2,3-dioxygenase (IDO), which plays a major role in tryptophan catabolism. IDO is an intracellular monomeric enzyme that is also responsible for breaking down and consuming tryptophan in the Kynurenine pathway. Increased inflammation has been linked to decrease tryptophan concentrations and increase kynurenine levels. We tried to explain the role of inflammation by viral respiratory infections in causing depression.

Item Type: Article
Creators:
CreatorsEmail
Karimi, Z.UNSPECIFIED
Chenari, M.UNSPECIFIED
Rezaie, F.UNSPECIFIED
Karimi, S.UNSPECIFIED
Parhizgari, N.UNSPECIFIED
Mokhtari-Azad, T.UNSPECIFIED
Keywords: Depression Viral infection Inflammation Indoleamine-pyrrole 2,3-dioxygenase Kynurenine indoleamine 2,3-dioxygenase immune activation influenza inflammation cytokines responses ido association disorders pathophysiology Neurosciences & Neurology Pharmacology & Pharmacy
Divisions:
Page Range: pp. 199-210
Journal or Publication Title: Clinical Psychopharmacology and Neuroscience
Journal Index: ISI
Volume: 20
Number: 2
Identification Number: https://doi.org/10.9758/cpn.2022.20.2.199
ISSN: 1738-1088
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3991

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