Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Clinical impact of Candida respiratory tract colonization and acute lung infections in critically ill patients with COVID-19 pneumonia

Mon Mar 4 22:46:21 2024

(2022) Clinical impact of Candida respiratory tract colonization and acute lung infections in critically ill patients with COVID-19 pneumonia. Microbial Pathogenesis. p. 6. ISSN 0882-4010

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Abstract

Coronavirus disease 2019 (COVID-19), which is attributable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been causing a worldwide health issue. Airways colonization by Candida spp. is prevalent among patients on automatic ventilation in intensive care units (ICUs). This research aimed to ascertain the risk factors and roles of Candida spp. respiratory tract colonization, and Candida lung infection during the progression of COVID-19 pneumonia in critically ill patients. In total, Candida spp. were recovered in 69 from 100 immunosuppressed patients with COVID-19. Bronchoscopy was used to collect the Bronchoalveolar lavage (BAL) specimens. For the identification of Candida spp. PCR sequencing was done using the ITS1 and ITS4 primers. The amplification of the HWP1 gene was conducted to identify the Candida albicans complex. The antifungal activities of fluconazole, itraconazole, voriconazole, amphotericin B and caspofungin against Candida spp. were evaluated using the Clinical and Laboratory Standards Institute M60. In 63.77 of the patients, Candida respiratory colonization at D0 and D14 had no impact on the severity of COVID-19. In comparison to C. albicans strains, Candida respiratory disorder with C. glabrata had influenced the severity of COVID-19 for critically ill patients following adjustment for the risk factors of COVID-19 (P < 0.05). Amphotericin B and caspofungin showed superior activity against all Candida spp. All antifungal agents showed 100 sensitivity against the two C. africana strains. Our observation on patients who used automatic ventilation, respiratory colonization by Candida spp. was not seen to influence the infection or death caused by COVID-19. Amphotericin B and caspofungin showed superior activity against all Candida spp. and were recommended for the treatment regime of pulmonary candidiasis associated with COVID-19 infection. Although "Candida pneumonia" is rarely being reported in critically ill patients, Candida airway colonization mainly by Candida albicans is common especially among patients with diabetes, malignancies, and kidney disorders.

Item Type: Article
Creators:
CreatorsEmail
Erami, M.UNSPECIFIED
Raiesi, O.UNSPECIFIED
Momen-Heravi, M.UNSPECIFIED
Getso, M. I.UNSPECIFIED
Fakhrehi, M.UNSPECIFIED
Mehri, N.UNSPECIFIED
Yarahmadi, M.UNSPECIFIED
Amiri, S.UNSPECIFIED
Raissi, V.UNSPECIFIED
Hashemi, S. J.UNSPECIFIED
Keywords: COVID-19 SARS-CoV-2 Candida Bronchoalveolar lavage Mechanical ventilation Antifungal agents ventilator-associated pneumonia albicans spp. identification outcomes Immunology Microbiology
Divisions:
Page Range: p. 6
Journal or Publication Title: Microbial Pathogenesis
Journal Index: ISI
Volume: 166
Identification Number: https://doi.org/10.1016/j.micpath.2022.105520
ISSN: 0882-4010
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3989

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