Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Tuberculosis challenges: Resistance, co-infection, diagnosis, and treatment

Thu Feb 2 18:05:17 2023

(2022) Tuberculosis challenges: Resistance, co-infection, diagnosis, and treatment. European Journal of Microbiology and Immunology. pp. 1-17. ISSN 2062-8633

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Abstract

Early diagnosis of tuberculosis (TB), followed by effective treatment, is the cornerstone of global TB control efforts. An estimated 3 million cases of TB remain undetected each year. Early detection and effective management of TB can prevent severe disease and reduce mortality and transmission. Intrinsic and acquired drug resistance of Mycobacterium tuberculosis (MTB) severely restricted the anti-TB therapeutic options, and public health policies are required to preserve the new medications to treat TB. In addition, TB and HIV frequently accelerate the progression of each other, and one disease can enhance the other effect. Overall, TB-HIV co-infections show an adverse bidirectional interaction. For HIV-infected patients, the risk of developing TB disease is approximately 22 times higher than for persons with a protective immune response. Analysis of the current TB challenges is critical to meet the goals of the end TB strategy and can go a long way in eradicating the disease. It provides opportunities for global TB control and demonstrates the efforts required to accelerate eliminating TB. This review will discuss the main challenges of the TB era, including resistance, co-infection, diagnosis, and treatment.

Item Type: Article
Creators:
CreatorsEmail
Heidary, M.UNSPECIFIED
Shirani, M.UNSPECIFIED
Moradi, M.UNSPECIFIED
Goudarzi, M.UNSPECIFIED
Pouriran, R.UNSPECIFIED
Rezaeian, T.UNSPECIFIED
Khoshnood, S.UNSPECIFIED
Keywords: tuberculosis Mycobacterium tuberculosis coinfection diagnosis treatment resistance intrinsic macrolide resistance mycobacterium-tuberculosis multidrug-resistant latent tuberculosis pulmonary tuberculosis drug-resistance hepatitis-b pyrazinamide resistance childhood tuberculosis laboratory diagnosis Microbiology
Divisions:
Page Range: pp. 1-17
Journal or Publication Title: European Journal of Microbiology and Immunology
Journal Index: ISI
Volume: 12
Number: 1
Identification Number: https://doi.org/10.1556/1886.2021.00021
ISSN: 2062-8633
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3986

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