Abstract

Duloxetine is a series of tricyclic antidepressants that have the potential inhibitory properties of histamine H1 and H2 receptors. The present study aimed at evaluating the effect of a Systematic Review of Investigating the Effect of Duloxetine on the pain status of patients with SCIs. The present systematic review was conducted observing principles of publication ethics and guidelines of systematic reviews and meta-analyzes (PARISMA) aimed to investigate the effect of duloxetine on the pain status of patients with SCIs during 2010-2021. Two researchers who were proficient in SCIs and reviewed review articles performed the search. A checklist including the author's name, publication date, Outcomes, Control, Intervention, Population, and Study design was used for data collection. Using Excel 2007 Software, the collected data were classified and the final report. The result showed that 202 articles were included in the study in the first stage. In the first stage, 154 articles were deleted due to the irrelevance of the title and method of the article. Also, 34 articles were done due to duplication of articles, and 8 articles were done due to non-human studies. Finally, 6 articles entered the systematic review stage. In all reviewed articles, it was shown that doxepin effectively reduces pain and can reduce pain. While in the placebo group, patients' pain did not decrease. Due to the effect of duloxetine on reducing pain in patients with SCIs, it is suggested that duloxetine can reduce pain in patients.