Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

SARS-CoV-2 triggering autoimmune diseases

Thu Feb 2 17:59:16 2023

(2022) SARS-CoV-2 triggering autoimmune diseases. Cytokine. p. 8. ISSN 1043-4666

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Abstract

Autoimmunity, hyperstimulation of the immune system, can be caused by a variety of reasons. Viruses are thought to be important environmental elements that contribute to the development of autoimmune antibodies. It seems that viruses cause autoimmunity with mechanisms such as molecular mimicry, bystander activation of T cells, transient immunosuppression, and inflammation, which has also been seen in post-Covid-19 autoimmunity. Infection of respiratory epithelium by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dysregulates the immune response, triggers both innate and acquired immunity that led to the immune system's hyperactivation, excessive cytokine secretion known as "cytokine storm, " and finally acute respiratory distress syndrome (ARDS) associated with high mortality. Any factor in the body that triggers chronic inflammation can contribute to autoimmune disease, which has been documented during the Covid-19 pandemic. It has been observed that some patients produce autoantibody and autoreactive CD4(+) and CD8(+) T cells, leading to the loss of self-tolerance. However, there is a scarcity of evidence defining the precise molecular interaction between the virus and the immune system to elicit autoreactivity. Here, we present a review of the relevant immunological findings in Covid-19 and the current reports of autoimmune disease associated with the disease.

Item Type: Article
Creators:
CreatorsEmail
Mobasheri, L.UNSPECIFIED
Nasirpour, M. H.UNSPECIFIED
Masoumi, E.UNSPECIFIED
Azarnaminy, A. F.UNSPECIFIED
Jafari, M.UNSPECIFIED
Esmaeili, S. A.UNSPECIFIED
Keywords: SARS-CoV-2 Covid-19 Autoimmune disease Autoimmunity Cytokine molecular mimicry tolerogenic probiotics clinical-features myasthenia-gravis t-cells covid-19 immunopathogenesis pathogenesis vaccination expression Biochemistry & Molecular Biology Cell Biology Immunology
Divisions:
Page Range: p. 8
Journal or Publication Title: Cytokine
Journal Index: ISI
Volume: 154
Identification Number: https://doi.org/10.1016/j.cyto.2022.155873
ISSN: 1043-4666
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3977

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