Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Bacteria-derived chimeric toxins as potential anticancer agents

Thu Feb 2 18:00:02 2023

(2022) Bacteria-derived chimeric toxins as potential anticancer agents. Frontiers in Oncology. p. 17. ISSN 2234-943X

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Abstract

Cancer is one of the major causes of death globally, requiring everlasting efforts to develop novel, specific, effective, and safe treatment strategies. Despite advances in recent years, chemotherapy, as the primary treatment for cancer, still faces limitations such as the lack of specificity, drug resistance, and treatment failure. Bacterial toxins have great potential to be used as anticancer agents and can boost the effectiveness of cancer chemotherapeutics. Bacterial toxins exert anticancer effects by affecting the cell cycle and apoptotic pathways and regulating tumorigenesis. Chimeric toxins, which are recombinant derivatives of bacterial toxins, have been developed to address the low specificity of their conventional peers. Through their targeting moieties, chimeric toxins can specifically and effectively detect and kill cancer cells. This review takes a comprehensive look at the anticancer properties of bacteria-derived toxins and discusses their potential applications as therapeutic options for integrative cancer treatment.

Item Type: Article
Creators:
CreatorsEmail
Khoshnood, S.UNSPECIFIED
Fathizadeh, H.UNSPECIFIED
Neamati, F.UNSPECIFIED
Negahdari, B.UNSPECIFIED
Baindara, P.UNSPECIFIED
Abdullah, M. A.UNSPECIFIED
Haddadi, M. H.UNSPECIFIED
Keywords: anticancer chimeric toxin bacterial toxins immunotoxin affibody bacteria-derived chimeric toxin exotoxin A ligand-based immunotoxins diphtheria-toxin recombinant immunotoxin fusion protein pseudomonas exotoxin denileukin diftitox cancer-cells expression therapy target differentiation Oncology
Divisions:
Page Range: p. 17
Journal or Publication Title: Frontiers in Oncology
Journal Index: ISI
Volume: 12
Identification Number: https://doi.org/10.3389/fonc.2022.953678
ISSN: 2234-943X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3975

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