Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Correlation of Homocysteine with Cerebral Hemodynamic Abnormality, Endothelial Dysfunction Markers, and Cognition Impairment in Patients with Traumatic Brain Injury

Thu Aug 18 17:16:48 2022

(2017) Correlation of Homocysteine with Cerebral Hemodynamic Abnormality, Endothelial Dysfunction Markers, and Cognition Impairment in Patients with Traumatic Brain Injury. World Neurosurgery. pp. 70-79. ISSN 1878-8750

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Abstract

OBJECTIVE: This study aimed to assess any correlation between serum levels of homocysteine (Hcy) and markers of cerebral hemodynamics, endothelial dysfunction, and cognition impairment in patients with traumatic brain injury (TBI). METHODS: By a cross-sectional study, all clinical data and serum levels of homocysteine of 85 TBI patients were collected. The pulsatility indices (PIs) of the middle cerebral artery were recorded by transcranial color-coded Doppler ultrasonography and cerebrovascular reactivity was measured by the increase in middle cerebral artery flow velocity in response to 5 inhaled CO2. Serum levels of intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion moleculee1 (VCAM-1), cognition status by Montreal Cognitive Assessment, and Mini-Mental State Examination were measured in all participants. RESULTS: Totally, 85 patients including 51.76 male and the mean age of 54.48 years were studied. The level of Hcy in patients who died in the hospital or during 6 months after TBI was significantly higher than in survivors (P = 0.045, P = 0.020, respectively). Also, the levels of ICAM-1, VCAM-1, and PI in deceased patients were higher than their figures in survivors in both hospital and 6-month follow-ups (P = 0.450, P = 0.000; P = 0.072, P = 0.000, P = 0.090, and P = 0.000, respectively). Cerebrovascular reactivity in deceased patients was significantly lower than that in alive individuals (P = 0.008 and P = 0.000, respectively). A significant correlation was found between Hcy with cognition impairment according to Montreal Cognitive Assessment, Mini-Mental State Examination, and cerebral hemodynamic status according to PI (P = 0.000 for all). Also, this correlation was shown between Hcy with ICAM-1 and VCAM-1 in hospital and 6-month follow-ups (P = 0.000 for both). CONCLUSION: Hcy has a significant correlation with markers of cerebrovascular, endothelial, and cognition abnormality in TBI patients.

Item Type: Article
Creators:
CreatorsEmail
Hatefi, M.UNSPECIFIED
Behzadi, S.UNSPECIFIED
Dastjerdi, M. M.UNSPECIFIED
Ghahnavieh, A. A.UNSPECIFIED
Rahmani, A.UNSPECIFIED
Mahdizadeh, F.UNSPECIFIED
Ahmadi, M. R. H.UNSPECIFIED
Asadollahi, K.UNSPECIFIED
Keywords: Cerebral hemodynamics Cognition impairment Endothelial dysfunction Homocysteine Traumatic brain injury transcranial doppler head-injury risk-factor disease disorders hyperhomocysteinemia communication cells Neurosciences & Neurology Surgery
Divisions:
Page Range: pp. 70-79
Journal or Publication Title: World Neurosurgery
Journal Index: ISI
Volume: 97
Identification Number: https://doi.org/10.1016/j.wneu.2016.09.080
ISSN: 1878-8750
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/397

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