Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Antibacterial activity of chitosan-based nanohybrid membranes against drug-resistant bacterial isolates from burn wound infections

Wed Feb 8 11:26:21 2023

(2022) Antibacterial activity of chitosan-based nanohybrid membranes against drug-resistant bacterial isolates from burn wound infections. Archives of Microbiology. p. 6. ISSN 0302-8933

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Abstract

Biocompatible and non-toxic properties of chitosan make it a candidate with excellent application prospects in developing wound dressing conjugate compounds. Six different chitosan-based nanohybrid membranes were evaluated against multidrug-resistant bacterial isolates. Different combinations of chitosan, ciprofloxacin (CIP), biofunctionalized montmorillonite (MMT), and montmorillonite with sulfate chains (SMMT) were provided, and their antibacterial activity was assessed using the colony count method. Totally, 27 drug-resistant isolates, including 6x methicillin-resistant Staphylococcus aureus, 7 vancomycin-resistant Enterococcus faecalis, 4 Acinetobacterbaumannii, and 10 Pseudomonas aeruginosa isolates were identified from burn wound infections. Chitosan and montmorillonite did not show significant antibacterial effect (p > 0.05), but chitosan/SMMT/CIP was the most effective nanocomposite (p < 0.01). Chitosan-based nanocomposites with ciprofloxacin could effectively reduce the susceptibility of drug-resistant bacterial isolates. Bacterial targeting using nanosystems provides an opportunity for effective antibiotic treatment by improving antibacterial efficacy.

Item Type: Article
Creators:
CreatorsEmail
Amiri, P.UNSPECIFIED
Kardan-Yamchi, J.UNSPECIFIED
Kazemian, H.UNSPECIFIED
Rezaei, F.UNSPECIFIED
Keywords: Chitosan Montmorillonite Ciprofloxacin Antibacterial activity Burn wound Nanohybrid membranes antimicrobial resistance impact Microbiology
Divisions:
Page Range: p. 6
Journal or Publication Title: Archives of Microbiology
Journal Index: ISI
Volume: 204
Number: 6
Identification Number: https://doi.org/10.1007/s00203-022-02918-6
ISSN: 0302-8933
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3967

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