Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Fracture risk in patients with type 2 diabetes mellitus and possible risk factors: a systematic review and meta-analysis

Tue Jul 23 08:33:50 2024

(2017) Fracture risk in patients with type 2 diabetes mellitus and possible risk factors: a systematic review and meta-analysis. Therapeutics and Clinical Risk Management. p. 14. ISSN 1178-203X

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Aim: Patients with type 2 diabetes mellitus (T2DM) have an increased risk of bone fractures. A variable increase in fracture risk has been reported depending on skeletal site, diabetes duration, study design, insulin use, and so on. The present meta-analysis aimed to investigate the association between T2DM with fracture risk and possible risk factors. Methods: Different databases including PubMed, Institute for Scientific Information, and Scopus were searched up to May 2016. All epidemiologic studies on the association between T2DM and fracture risk were included. The relevant data obtained from these papers were analyzed by a random effects model and publication bias was assessed by funnel plot. All analyses were done by R software (version 3.2.1) and STATA (version 11.1). Results: Thirty eligible studies were selected for the meta-analysis. We found a statistically significant positive association between T2DM and hip, vertebral, or foot fractures and no association between T2DM and wrist, proximal humerus, or ankle fractures. Overall, T2DM was associated with an increased risk of any fracture (summary relative risk = 1.05, 95 confidence interval: 1.04, 1.06) and increased with age, duration of diabetes, and insulin therapy. Conclusion: Our findings strongly support an association between T2DM and increased risk of overall fracture. These findings emphasize the need for fracture prevention strategies in patients with diabetes.

Item Type: Article
Mohamadpour, M.UNSPECIFIED
Shirzadpour, E.UNSPECIFIED
Mohamadpour, S.UNSPECIFIED
Keywords: diabetes mellitus fractures bone osteoporosis risk factors meta-analysis bone-mineral density population-based cohort hip fracture vertebral fractures osteoporotic fractures older individuals korean patients distal forearm elderly-men women Health Care Sciences & Services
Page Range: p. 14
Journal or Publication Title: Therapeutics and Clinical Risk Management
Journal Index: ISI
Volume: 13
Identification Number:
ISSN: 1178-203X
Depositing User: مهندس مهدی شریفی

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