Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Thymol Nanopolymer Synthesis and Its Effects on Morphine Withdrawal Syndrome in Comparison With Clonidine in Rats

Thu Feb 2 17:52:47 2023

(2022) Thymol Nanopolymer Synthesis and Its Effects on Morphine Withdrawal Syndrome in Comparison With Clonidine in Rats. Frontiers in Behavioral Neuroscience. p. 13. ISSN 1662-5153

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Abstract

The drug delivery system is valuable in the treatment of the disease. A nanopolymer as a thymol and Thymbra spicata release system was synthesized and its effects on morphine withdrawal syndrome in comparison with clonidine in rats were studied. The nanopolymer was characterized by different methods, namely, IR, HNMR, CNMR, GPC, DLS, and AFM. Thymol in T. spicata extract was assessed. The loading and release rate of thymol and T. spicata extract on the nanopolymer were evaluated by HPLC. The median lethal dose (LD50) of the T. spicata extract, thymol, extract nanopolymer, and thymol nanopolymer was studied. The frequency of jumping, rearing, and teeth chattering in naloxone-induced morphine withdrawal syndrome was studied. Synthesized nanopolymer was desirable as a carrier for the drug. The loaded amount of extract and thymol on nanopolymer was estimated 55 +/- 3.2 and 48 +/- 2.6 and the drug released was 71 and 68, respectively. LD50 of the T. spicata extract, thymol, extract nanopolymer, and thymol nanopolymer was 975, 580, 1,250, and 650 mg/kg, respectively. This study showed that thymol nanopolymer was more effective than clonidine to reduce the frequency of morphine withdrawal symptoms. Our results suggest that T. spicata extract, thymol, extract nanopolymer, and thymol nanopolymer are mighty in reducing the narcotic withdrawal signs. The mechanism of action and therapeutic potential is maybe similar to clonidine.

Item Type: Article
Creators:
CreatorsEmail
Moayeri, A.UNSPECIFIED
Mehdizadeh, R.UNSPECIFIED
Karimi, E.UNSPECIFIED
Aidy, A.UNSPECIFIED
Ghaneialvar, H.UNSPECIFIED
Abbasi, N.UNSPECIFIED
Keywords: nano polymer thymol Thymbra spicata morphine withdrawal syndrome opioid-dependence hyperbranched polymers antioxidant activity subchronic toxicity herbal medicines aqueous-solution in-vitro nanoparticle copolymers release Behavioral Sciences Neurosciences & Neurology
Divisions:
Page Range: p. 13
Journal or Publication Title: Frontiers in Behavioral Neuroscience
Journal Index: ISI
Volume: 16
Identification Number: https://doi.org/10.3389/fnbeh.2022.843951
ISSN: 1662-5153
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3899

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