Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Ketorolac and Predicted Severe Acute Pancreatitis: A Randomized, Controlled Clinical Trial

Fri Oct 7 03:36:46 2022

(2022) Ketorolac and Predicted Severe Acute Pancreatitis: A Randomized, Controlled Clinical Trial. Clinical medicine & research. ISSN 1554-6179 (Electronic) 1539-4182 (Linking)

Full text not available from this repository.

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/34996820

Abstract

Objective: We evaluated the effect of ketorolac on reducing the severity of acute pancreatitis.Design: Randomized clinical trial.Setting: University hospital.Participants: Fifty six adult patients, with predicted severe acute pancreatitis, were randomly divided into two groups.Methods: The patients in the study group received intravenous ketorolac, 10 mg, three times daily from the time of enrollment for a maximum of five days as needed along with standard medical treatment. Primary outcome measure was the change in the serum level of high sensitive c reactive protein (hs-CRP). Patients were also followed up in terms of hospitalization duration, need for ICU, development of organ failure, persistent organ failure, pancreatic necrosis, nutritional assessment, and mortality. The study was continued to gather clinical follow up information up to four months.Results: Serum level of hs-CRP was significantly lower in the ketorolac group compared with the control group on days 3, 4, and 5. There was no significant difference in organ failure, pseudocyst formation, acute necrotic collection, mortality and ICU transfer between two groups. Days of hospitalization were significantly lower in the study group. The feeding start time was significantly shorter in the study group with no need for tube feeding in the ketorolac group. Frequency of NPO (not per oral) was significantly lower in the ketorolac group.Conclusion: The use of ketorolac may improve feeding outcomes and shorten length of hospitalization in predicted severe acute pancreatitis.

Item Type: Article
Creators:
CreatorsEmail
Shariatpanahi, Z. V.UNSPECIFIED
Shahbazi, S.UNSPECIFIED
Shahbazi, E.UNSPECIFIED
Keywords: Crp Enteral nutrition Feeding Mortality Pancreas
Divisions:
Journal or Publication Title: Clinical medicine & research
Journal Index: Pubmed
Identification Number: https://doi.org/10.3121/cmr.2021.1663
ISSN: 1554-6179 (Electronic) 1539-4182 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3867

Actions (login required)

View Item View Item