Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Antiviral effects of azithromycin: A narrative review

Fri Oct 7 02:25:35 2022

(2022) Antiviral effects of azithromycin: A narrative review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. p. 112682. ISSN 1950-6007 (Electronic) 0753-3322 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/35131658

Abstract

Viral infections have a great impact on human health. The urgent need to find a cure against different viruses led us to investigations in a vast range of drugs. Azithromycin (AZT), classified as a macrolide, showed various effects on different known viruses such as severe acute respiratory syndrome coronavirus (SARS-CoV), Zika, Ebola, Enterovirus (EVs) and Rhinoviruses (RVs), and Influenza A previously; namely, these viruses, which caused global concerns, are considered as targets for AZT different actions. Due to AZT background in the treatment of known viral infections mentioned above (which is described in this study), in the early stages of COVID-19 (a new zoonotic disease caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) development, AZT drew attention to itself due to its antiviral and immunomodulatory effects as a valuable candidate for COVID-19 treatment. AZT usage instructions for treating different viral infections have always been under observation, and COVID-19 is no exception. There are still debates about the use of AZT in COVID-19 treatment. However, eventually, novel researches convinced WHO to announce the discontinuation of AZT use (alone or in combination with hydroxychloroquine) in treating SARS-CoV-2 infection. This research aims to study the structure of all of the viruses mentioned above and the molecular and clinical effects of AZT against the virus.

Item Type: Article
Creators:
CreatorsEmail
Khoshnood, S.UNSPECIFIED
Shirani, M.UNSPECIFIED
Dalir, A.UNSPECIFIED
Moradi, M.UNSPECIFIED
Haddadi, M. H.UNSPECIFIED
Sadeghifard, N.UNSPECIFIED
Birjandi, F. S.UNSPECIFIED
Yashmi, I.UNSPECIFIED
Heidary, M.UNSPECIFIED
Keywords: Anti-Bacterial Agents Antiviral Agents/pharmacology/*therapeutic use Azithromycin/pharmacology/*therapeutic use COVID-19/*drug therapy Ebolavirus/drug effects Humans Influenza A virus/drug effects SARS Virus/drug effects SARS-CoV-2/drug effects Zika Virus/drug effects Azithromycin Covid-19 Ebola Enterovirus and Rhinoviruses Influenza A SARS-CoV SARS-CoV-2 Viral infections Zika
Divisions:
Page Range: p. 112682
Journal or Publication Title: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Journal Index: Pubmed
Volume: 147
Identification Number: https://doi.org/10.1016/j.biopha.2022.112682
ISSN: 1950-6007 (Electronic) 0753-3322 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3859

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