Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Anti-leishmanial effects of resveratrol and resveratrol nanoemulsion on Leishmania major

Tue Dec 6 01:37:23 2022

(2022) Anti-leishmanial effects of resveratrol and resveratrol nanoemulsion on Leishmania major. Bmc Microbiology. p. 14. ISSN 1471-2180

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Abstract

Background Leishmaniasis is a vector-borne disease that is endemic in the tropical and sub-tropical areas of the world. Low efficacy and high cytotoxicity of the current treatment regimens for leishmaniasis is one of the most important health problems. In this experimental study, anti-leishmanial effects of different concentrations of resveratrol and resveratrol nano-emulsion (RNE) were assessed. Methods RNE was prepared using the probe ultra-sonication method. The cytotoxicity was evaluated using the MTT technique on the L929 cell line. The anti-leishmanial activities on promastigotes of leishmania were assessed using vital staining and infected BALB/c mice were used to assess the in vivo anti-leishmanial effects. Results In vitro and in vivo assays revealed that all concentrations of resveratrol and RNE had valuable inhibitory effects against Leishmania major in comparison to the control group (P < 0.05). The half maximal inhibitory concentration (IC50) values were calculated as 16.23 and 35.71 mu g/mL for resveratrol and RNE, respectively. Resveratrol and RNE showed no cytotoxicity against the L929 cell line. Conclusions According to the potent in vitro and in vivo anti-leishmanial activity of RNE at low concentration against L. major, we suggest that it could be a promising anti-leishmanial therapeutic against L. major in the future.

Item Type: Article
Creators:
CreatorsEmail
Mousavi, P.UNSPECIFIED
Esboei, B. R.UNSPECIFIED
Pourhajibagher, M.UNSPECIFIED
Fakhar, M.UNSPECIFIED
Shahmoradi, Z.UNSPECIFIED
Hejazi, S. H.UNSPECIFIED
Hassannia, H.UNSPECIFIED
Omran, A. N.UNSPECIFIED
Hasanpour, H.UNSPECIFIED
Keywords: Anti-leishmanial activity Leishmania major Resveratrol Resveratrol nanoemulsion cutaneous leishmaniasis replication infection l. Microbiology
Divisions:
Page Range: p. 14
Journal or Publication Title: Bmc Microbiology
Journal Index: ISI
Volume: 22
Number: 1
Identification Number: https://doi.org/10.1186/s12866-022-02455-8
ISSN: 1471-2180
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3850

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