Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Antiinflammatory potential of nano-curcumin as an alternative therapeutic agent for the treatment of mild-to-moderate hospitalized COVID-19 patients in a placebo-controlled clinical trial

Wed Sep 28 20:00:54 2022

(2022) Antiinflammatory potential of nano-curcumin as an alternative therapeutic agent for the treatment of mild-to-moderate hospitalized COVID-19 patients in a placebo-controlled clinical trial. Phytotherapy Research. pp. 1023-1031. ISSN 0951-418X

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Abstract

The present study conducted a placebo-controlled clinical trial to evaluate the impact of nano-curcumin on the inflammatory cytokines in mild-to-moderate hospitalized COVID-19 patients. A total of 60 COVID-19 patients were randomly divided into nano-curcumin and control groups, and then they received 240 mg/day nano-curcumin for 7 days. The clinical manifestation and laboratory parameters in patients were recorded on days 0 and seven. Also, SYBR Green real-time PCR and ELISA techniques were implicated in assessing the mRNA expression of IFN-gamma, IL-1 beta, IL-6, MCP-1, and TNF-alpha and the serum levels of IL-1 beta, IL-6, and TNF-alpha inflammatory mediators, respectively. Although the clinical manifestations and laboratory parameters improved via the nano-curcumin treatment, the mRNA expression of IFN-gamma (p = 0.006) and TNF-alpha (p = 0.04) were significantly reduced. Besides, a considerable difference was observed between the nano-curcumin and control groups in the expression of IFN-gamma (p = 0.001), IL-1 beta (p = 0.0002), and IL-6 (p = 0.008). In addition, there was a significant difference between the nano-curcumin and control groups in the serum levels of IL-1 beta (p = 0.042). The evidence demonstrated that nano-curcumin could be implicated as a complementary medication to act as an antiinflammatory agent and inhibit inflammatory complications.

Item Type: Article
Creators:
CreatorsEmail
Asadirad, A.UNSPECIFIED
Nashibi, R.UNSPECIFIED
Khodadadi, A.UNSPECIFIED
Ghadiri, A. A.UNSPECIFIED
Sadeghi, M.UNSPECIFIED
Aminian, A.UNSPECIFIED
Dehnavi, S.UNSPECIFIED
Keywords: coronavirus disease-2019 curcumin cytokine storm inflammatory cytokines severe acute respiratory syndrome-coronavirus-2 metaanalysis infection Pharmacology & Pharmacy
Divisions:
Page Range: pp. 1023-1031
Journal or Publication Title: Phytotherapy Research
Journal Index: ISI
Volume: 36
Number: 2
Identification Number: https://doi.org/10.1002/ptr.7375
ISSN: 0951-418X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3847

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