Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Neuraminidase Inhibitors During Pregnancy and Adverse Birth Outcomes: A Meta-Analysis

Fri Oct 7 02:24:49 2022

(2022) Neuraminidase Inhibitors During Pregnancy and Adverse Birth Outcomes: A Meta-Analysis. Biointerface Research in Applied Chemistry. pp. 5893-5900. ISSN 2069-5837

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Abstract

Neuraminidase inhibitors (NAIs) are commonly used to treat influenza and are also considered the potential treatment for COVID-19. The association of using NAIs during pregnancy with the risk of adverse birth defects has been investigated repeatedly by epidemiological studies; however, results are largely inconsistent. We herein performed this meta-analysis to investigate the true association of NAIs with adverse birth defects, including preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA). A systematic search was performed through PubMed, Scopus, and Embase to indentify all pertinent studies; The ORs with their corresponding 95 CIs were extracted or calculated. Heterogeneity was assessed using the Cochran Q test and the I-2 statistic. A random-effect model was used for this meta-analysis due to existing heterogeneity. Overall, eight studies were included in our analysis, meta-analysis using a random-effect model showed that NAIs during pregnancy reduced the risk of LBW (OR=0.78, 95 CI=0.66-0.91) and SGA (OR=0.76, 95 CI=0.670.86) but is not associated with PTB (OR=1.01, 95 CI=0.87-1.16). Results of the present study suggested that NAIs during pregnancy are safe and may reduce the risk of LBW and SGA. However, further studies from different ethnic populations are warranted to confirm our results.

Item Type: Article
Creators:
CreatorsEmail
Forghanifar, M.UNSPECIFIED
Jamali, S.UNSPECIFIED
Mobasher, Z.UNSPECIFIED
Hashemi, M.UNSPECIFIED
Fahimi, R.UNSPECIFIED
Pakzad, R.UNSPECIFIED
Sezavar, A. H.UNSPECIFIED
Keywords: neuraminidase inhibitors pregnancy birth defects birth outcomes meta-analysis influenza oseltamivir Chemistry
Divisions:
Page Range: pp. 5893-5900
Journal or Publication Title: Biointerface Research in Applied Chemistry
Journal Index: ISI
Volume: 12
Number: 5
Identification Number: https://doi.org/10.33263/briac125.58935900
ISSN: 2069-5837
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3846

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