Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Evaluation the Healing Potential of Oleuropein on Second-Degree Burn Wounds in a Rat Model

Mon Sep 26 13:20:04 2022

(2022) Evaluation the Healing Potential of Oleuropein on Second-Degree Burn Wounds in a Rat Model. Jundishapur Journal of Natural Pharmaceutical Products. p. 9. ISSN 1735-7780

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Abstract

Background: Skin burn is one of the most common complications throughout the world. Olive derivatives have been used for the treatment of skin lesions in Iran. Oleuropein is one of the main constituents of olive leaves. Objectives: The aim of the present study was to evaluate the healing effects of oleuropein cream on second-degree burns wounds in a rat model. Methods: This experimental study was performed on 72 male Wistar rats. Superficial second-degree burns were induced in the hairless back of the animals. Then, they were randomly divided into six equal groups. The burnt area in the first group was covered twice a day with normal saline, in the second group with eucerin, in the third group with 1 silver sulfadiazine and in the fourthsixth groups, oleuropein cream was applied topically. To evaluate the efficacy of treatment, four rats in each group were euthanized on days 4, 9, and 14, and their skin was processed for wound contraction, glutathione (GSH) level, malondialdehyde (MDA) level, hydroxyproline (HP) content, inflammatory factors (transforming growth factor beta TGF-beta and interleukin 6 IL-6), and histological examination. Results: In comparison with untreated control rats, the daily application of 5% oleuropein cream significantly increased wound contraction, HP content, and GSH level over time. Moreover, it caused a significant reduction in inflammatory factors and MDA level. Histological examination confirmed the results. Conclusions: This study indicated that oleuropein has therapeutic value in treating burn wounds and thus supports its traditional use.

Item Type: Article
Creators:
CreatorsEmail
Ahmadi, I.UNSPECIFIED
Foruozandeh, H.UNSPECIFIED
Yekke, F.UNSPECIFIED
Keywords: Burn Wound Healing Oleuropein Rat antioxidant olive hydroxyproline extract tissue Pharmacology & Pharmacy
Divisions:
Page Range: p. 9
Journal or Publication Title: Jundishapur Journal of Natural Pharmaceutical Products
Journal Index: ISI
Volume: 17
Number: 1
Identification Number: https://doi.org/10.5812/jjnpp.114568
ISSN: 1735-7780
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3838

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