Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Detection of efflux pump genes conferring multidrug resistance in clinical isolates of Acinetobacter Baumannii in Tehran province

Fri Oct 7 02:17:26 2022

(2022) Detection of efflux pump genes conferring multidrug resistance in clinical isolates of Acinetobacter Baumannii in Tehran province. Reviews in Medical Microbiology. pp. 31-36. ISSN 0954-139X

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Abstract

Objective: Acinetobacter baumannii is among the most common bacterial agents causing nosocomial infections in the world. In recent years, the antibiotic resistance of A. baumannii strains has shown an increasing trend, which may be resulted from the activity of efflux pumps. This study was carried out to determine the efflux pump genes associated with MDR in clinical isolates of A. baumannii in Tehran province. Methods: In this study, 200 clinical samples were collected, and were identified through standard biochemical tests. Then, for the selected antibiotics, the antibacterial susceptibility patterns were determined using disk diffusion method with and without inhibitors of efflux pumps of add adeH, adeB, adeG, adeF, and adeS that were determined by employing PCR according to the Clinical & Laboratory Standards Institute (CLSI 2020) guideline. Results: A total of 60 clinical isolates of A. baumannii were identified and later confirmed by the detection of blaOXA-51-like and 16S rRNA genes. The findings of this study show that 98.37 of A. baumannii isolates were 100 resistant against piperacillin, meropenem, cefotaxime, ceftriaxone, ceftazidime, ceftazidime, and ciprofloxaci n. In addition, 100 of all A. baumannii isolates possessed AdeFBJ, 95 adeH, 80 adeS, and 76.7 adeG efflux pumps. Conclusion: The majority of A. baumannii isolates had antibiotic efflux pumps, and more than 73 of A. baumannii isolates were indicated to be resistant to the target antibiotics, indicating the significant role of efflux pumps in the development of resistance against these antibiotics. Copyright (C) 2021 Wolters Kluwer Health, Inc. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Beikmohammadi, H.UNSPECIFIED
Viesy, S.UNSPECIFIED
Kaviani, R.UNSPECIFIED
Pouladi, I.UNSPECIFIED
Keywords: Acinetobacter baumannii antibiotic resistance efflux pump Microbiology
Divisions:
Page Range: pp. 31-36
Journal or Publication Title: Reviews in Medical Microbiology
Journal Index: ISI
Volume: 33
Number: 1
Identification Number: https://doi.org/10.1097/mrm.0000000000000255
ISSN: 0954-139X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3837

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