Repository of Research and Investigative Information

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Ilam University of Medical Sciences

Pooled Prevalence Estimate of Ocular Manifestations in COVID-19 Patients: A Systematic Review and Meta-Analysis

Thu Oct 6 08:07:42 2022

(2022) Pooled Prevalence Estimate of Ocular Manifestations in COVID-19 Patients: A Systematic Review and Meta-Analysis. Iranian Journal of Medical Sciences. pp. 2-14. ISSN 0253-0716

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Abstract

Background: There are reports of ocular tropism due to respiratory viruses such as severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Various studies have shown ocular manifestation in coronavirus disease-2019 (COVID-19) patients. We aimed to identify ophthalmic manifestations in COVID-19 patients and establish an association between ocular symptoms and SARS-CoV-2 infection. Methods: A systematic search of Medline, Scopus, Web of Science, Embase, and Cochrane Library was conducted for publications from December 2019 to April 2021. The search included MeSH terms such as SARS-CoV-2 and ocular manifestations. The pooled prevalence estimate (PPE) with 95 confidence interval (CI) was calculated using binomial distribution and random effects. The meta-regression method was used to examine factors affecting heterogeneity between studies. Results: Of the 412 retrieved articles, 23 studies with a total of 3,650 COVID-19 patients were analyzed. The PPE for any ocular manifestations was 23.77 (95 CI: 15.73-31.81). The most prevalent symptom was dry eyes with a PPE of 13.66 (95 CI: 5.01-25.51). The PPE with 95 CI for conjunctival hyperemia, conjunctival congestion/conjunctivitis, and ocular pain was 13.41(4.65-25.51), 9.14(6.13-12.15), and 10.34 (4.90-15.78), respectively. Only two studies reported ocular discomfort and diplopia. The results of meta-regression analysis showed that age and sample size had no significant effect on the prevalence of any ocular manifestations. There was no significant publication bias in our meta-analysis. Conclusion: There is a high prevalence of ocular manifestations in COVID-19 patients. The most common symptoms are dry eyes, conjunctival hyperemia, conjunctival congestion/conjunctivitis, ocular pain, irritation/itching/burning sensation, and foreign body sensation.

Item Type: Article
Creators:
CreatorsEmail
Soltani, S.UNSPECIFIED
Zandi, M.UNSPECIFIED
Ahmadi, S. E.UNSPECIFIED
Zarandi, B.UNSPECIFIED
Hosseini, Z.UNSPECIFIED
Rezayat, S. A.UNSPECIFIED
Abyadeh, M.UNSPECIFIED
Pakzad, I.UNSPECIFIED
Malekifar, P.UNSPECIFIED
Pakzad, R.UNSPECIFIED
Mozhgani, S. H.UNSPECIFIED
Keywords: COVID-19 SARS-CoV-2 Eye manifestations Systematic review Meta-analysis transmission sars-cov-2 General & Internal Medicine
Divisions:
Page Range: pp. 2-14
Journal or Publication Title: Iranian Journal of Medical Sciences
Journal Index: ISI
Volume: 47
Number: 1
Identification Number: https://doi.org/10.30476/ijms.2021.89475.2026
ISSN: 0253-0716
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3834

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