Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Promising effects of parasite-derived compounds on tumor regression: a systematic review of in vitro and in vivo studies

Sat Dec 10 02:47:13 2022

(UNSPECIFIED) Promising effects of parasite-derived compounds on tumor regression: a systematic review of in vitro and in vivo studies. Environmental Science and Pollution Research. p. 14. ISSN 0944-1344

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Abstract

The parasites are repeatedly confronting their host to take advantage of nutrients for multiplication and survival. In this sense, a wide spectrum of molecules is released from both sides, with immune-regulatory activity, accompanying this biological battle. Such parasites and their valuable molecules can be directed toward microbial-based cancer therapy. Herein, we contrived a systematic review to gather information on the antitumor activity of parasite-derived compounds. Following systematic search in Web of Science, ScienceDirect, Scopus, PubMed, ProQuest and Embase until 31 December 2019, a total number of 51 articles (54 datasets) were finally included in this review. Thirteen parasitic agents were found to possess possible antitumor activity, comprising protozoan species Toxoplasma gondii, Trypanosoma cruzi, Trichomonas vaginalis, Acanthamoeba castellanii, Besnoitia jellisoni, Leishmania major, Plasmodium yoelii, and Plasmodium lophurae, as well as parasitic helminths Toxocara canis, Echinococcus granulosus, Taenia crassiceps, Trichinella spiralis, and Schistosoma mansoni. Most experiments were done based on antigenic preparations from T. gondii (16 studies), E. granulosus (10 studies), T. spiralis (8 studies), and T. cruzi (6 studies). Possible antitumor properties of the selected parasites were revealed in this review. However, precise molecular basis of anticancer activity for each parasite remains to be elucidated in the future.

Item Type: Article
Creators:
CreatorsEmail
Asghari, A.UNSPECIFIED
Nourmohammadi, H.UNSPECIFIED
Majidiani, H.UNSPECIFIED
Shariatzadeh, S. A.UNSPECIFIED
Anvari, D.UNSPECIFIED
Shamsinia, S.UNSPECIFIED
Ghasemi, E.UNSPECIFIED
Shams, M.UNSPECIFIED
Basati, G.UNSPECIFIED
Keywords: Antitumor activity Parasites Cancers Tumors Systematic review toxoplasma lysate antigen trichinella-spiralis infection dendritic cell precursors trypanosoma-cruzi echinococcus-granulosus hygiene hypothesis antitumor immunity cancer development hydatid-disease gondii Environmental Sciences & Ecology
Divisions:
Page Range: p. 14
Journal or Publication Title: Environmental Science and Pollution Research
Journal Index: ISI
Identification Number: https://doi.org/10.1007/s11356-021-17090-5
ISSN: 0944-1344
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3832

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