Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The role of NK and NKT cells in the pathogenesis and improvement of multiple sclerosis following disease-modifying therapies

Sun Oct 2 23:23:22 2022

(2022) The role of NK and NKT cells in the pathogenesis and improvement of multiple sclerosis following disease-modifying therapies. Health Science Reports. p. 10.

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Abstract

Background Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS) that T cells become autoreactive by recognizing CNS antigens. Both innate and adaptive immune systems are involved in the pathogenesis of MS. In recent years, the impact of innate immune cells on MS pathogenesis has received more attention. CD56(bright) NK cells, as an immunoregulatory subset of NK cells, can increase the production of cytokines that modulate adaptive immune responses, whereas CD56(dim) NK cells are more active in cytolysis functions. These two main subsets of NK cells may have different effects on the onset or progression of MS. Invariant NKT (iNKT) cells are other immune cells involved in the control of autoimmune diseases; however, variant NKT (vNKT) cells, despite limited information, could play a role in MS remission via an immunoregulatory pathway. Aim We aimed to evaluate the influence of MS therapeutic agents on NK and NKT cells and NK cell subtypes. Materials and Methods The possible mechanism of each MS therapeutic agent has been presented here, focusing on the effects of different disease-modifying therapies on the number of NK and NKT subtypes. Results Expansion of CD56(bright) NK cells, reduction in the CD56(dim) cells, and enhancement in NKT cells are the more important innate immune cells alterations following the disease-modifying therapies. Conclusion Expansion of CD56(bright) NK cells or reduction in the CD56(dim) cells has been associated with a successful response to different treatments in MS. iNKT and vNKT cells could have beneficial effects on MS improving. It seems that they are enhanced due to some of MS drugs, leading to disease improvement. However, a reduction in the number of NKT cells could be due to the adverse effects of some of MS drugs on the bone marrow.

Item Type: Article
Creators:
CreatorsEmail
Ahmadi, A.UNSPECIFIED
Vastani, Z. F.UNSPECIFIED
Abounoori, M.UNSPECIFIED
Azizi, M.UNSPECIFIED
Labani-Motlagh, A.UNSPECIFIED
Mami, S.UNSPECIFIED
Mami, S.UNSPECIFIED
Keywords: immunotherapy multiple sclerosis natural killer cells nature killer T cells killer t-cells experimental autoimmune encephalomyelitis interferon-beta cerebrospinal-fluid immune regulation peripheral-blood dendritic cells animal-model daclizumab subsets Public, Environmental & Occupational Health General & Internal Medicine
Divisions:
Page Range: p. 10
Journal or Publication Title: Health Science Reports
Journal Index: ISI
Volume: 5
Number: 1
Identification Number: https://doi.org/10.1002/hsr2.489
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3830

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