Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Role of Oxidant-Antioxidant Status in Suicide Behavior in Kurdish Ethnicity

Thu Aug 18 11:33:59 2022

(2021) The Role of Oxidant-Antioxidant Status in Suicide Behavior in Kurdish Ethnicity. Basic and Clinical Neuroscience. pp. 667-673. ISSN 2008-126X

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Abstract

Introduction: Oxidative stress plays a critical role in the pathogenesis of neurodegenerative and neuropsychiatric disorders. However, its role in suicidal behavior has not been clarified yet. Consequently, we aimed to evaluate the oxidant-antioxidant status in the serum of suicide attempters in Ilam city. Methods: Fifty suicide attempters and 40 control subjects (volunteers) aged 18-35 years were studied in the current experiment. To consider the oxidant-antioxidant status, serum levels of Malondialdehyde (MDA), Nitric Oxide (NO), Superoxide Dismutase (SOD), and the Total Antioxidant Capacity (TAC) were measured. Results: Serum levels of SOD and TAC were significantly lower in the suicide attempters group compared to the controls. Furthermore, serum NO level was significantly higher in the suicide attempters compared to the control groups. Interestingly, the serum level of MDA was significantly lower in the suicide attempters compared to the control groups. Conclusion: The oxidative stress without MDA elevation, detected in suicide attempters, can be considered a biochemical hallmark in suicide behavior.

Item Type: Article
Creators:
CreatorsEmail
Oshnokhah, M.UNSPECIFIED
Bagheri, M.UNSPECIFIED
Ghaneialvar, H.UNSPECIFIED
Haghani, K.UNSPECIFIED
Khorshidi, A.UNSPECIFIED
Shahbazi, A.UNSPECIFIED
Salari, S.UNSPECIFIED
Keywords: Suicide behavior Oxidative stress TAC MDA SOD oxidative stress Neurosciences & Neurology
Divisions:
Page Range: pp. 667-673
Journal or Publication Title: Basic and Clinical Neuroscience
Journal Index: ISI
Volume: 12
Number: 5
Identification Number: https://doi.org/10.32598/bcn.2021.1917.1
ISSN: 2008-126X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/3822

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